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本文引用的文献

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Assessment of change in biofilm architecture by nutrient concentration using a multichannel microdevice flow system.利用多通道微流控装置流系统评估营养浓度对生物膜结构的改变。
J Biosci Bioeng. 2013 Mar;115(3):326-31. doi: 10.1016/j.jbiosc.2012.09.018. Epub 2012 Oct 22.
2
Identification of proteins associated with the Pseudomonas aeruginosa biofilm extracellular matrix.鉴定与铜绿假单胞菌生物膜细胞外基质相关的蛋白质。
J Proteome Res. 2012 Oct 5;11(10):4906-15. doi: 10.1021/pr300395j. Epub 2012 Sep 26.
3
Peptidoglycan plasticity in bacteria: stress-induced peptidoglycan editing by noncanonical D-amino acids.细菌中肽聚糖的可塑性：非典型 D-氨基酸诱导的应激肽聚糖编辑。
Microb Drug Resist. 2012 Jun;18(3):306-13. doi: 10.1089/mdr.2012.0009. Epub 2012 Mar 23.
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Should we stay or should we go: mechanisms and ecological consequences for biofilm dispersal.我们是该留下还是离开：生物膜分散的机制和生态后果。
Nat Rev Microbiol. 2011 Nov 28;10(1):39-50. doi: 10.1038/nrmicro2695.
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Reduced microbial attachment by D-amino acid-inhibited AI-2 and EPS production.通过 D-氨基酸抑制 AI-2 和 EPS 产生减少微生物附着。
Water Res. 2011 Nov 1;45(17):5796-804. doi: 10.1016/j.watres.2011.08.061. Epub 2011 Sep 3.
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Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development.D- 型氨基酸对金黄色葡萄球菌生物膜形成的抑制作用。
J Bacteriol. 2011 Oct;193(20):5616-22. doi: 10.1128/JB.05534-11. Epub 2011 Aug 19.
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Emerging knowledge of regulatory roles of D-amino acids in bacteria.细菌中 D-氨基酸的调控作用的新认识。
Cell Mol Life Sci. 2011 Mar;68(5):817-31. doi: 10.1007/s00018-010-0571-8. Epub 2010 Dec 14.
8
An update on Pseudomonas aeruginosa biofilm formation, tolerance, and dispersal.铜绿假单胞菌生物膜形成、耐受性及分散的最新进展
FEMS Immunol Med Microbiol. 2010 Aug;59(3):253-68. doi: 10.1111/j.1574-695X.2010.00690.x. Epub 2010 Apr 23.
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D-amino acids trigger biofilm disassembly.D-氨基酸引发生物膜解体。
Science. 2010 Apr 30;328(5978):627-9. doi: 10.1126/science.1188628.
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D-amino acids govern stationary phase cell wall remodeling in bacteria.D-氨基酸调控细菌的稳定期细胞壁重塑。
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用 D-氨基酸混合物处理铜绿假单胞菌 PAO1 流动生物膜，可显著降低细胞活力并增强基质生成。

Extensive reduction of cell viability and enhanced matrix production in Pseudomonas aeruginosa PAO1 flow biofilms treated with a D-amino acid mixture.

机构信息

Department of Materials Science and Chemical Engineering, Shizuoka University, Hamamatsu, Japan.

出版信息

Appl Environ Microbiol. 2013 Feb;79(4):1396-9. doi: 10.1128/AEM.02911-12. Epub 2012 Dec 7.

DOI:10.1128/AEM.02911-12
PMID:23220960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3568627/
Abstract

Treatment of Pseudomonas aeruginosa PAO1 flow biofilms with a D-amino acid mixture caused significant reductions in cell biomass by 75% and cell viability by 71%. No biofilm disassembly occurred, and matrix production increased by 30%, thereby providing a thick protective cover for remaining viable or persister cells.

摘要

用 D-氨基酸混合物处理铜绿假单胞菌 PAO1 流动生物膜，可使细胞生物量减少 75%，细胞活力减少 71%。没有发生生物膜解体，基质生成增加了 30%，从而为存活或持久细胞提供了厚厚的保护层。