内皮祖细胞捕获支架植入后的早期血管愈合
Early vascular healing after endothelial progenitor cell capturing stent implantation.
作者信息
Lehtinen Tuomas, Kiviniemi Tuomas O, Ylitalo Antti, Mikkelsson Jussi, Airaksinen Juhani K E, Karjalainen Pasi P
机构信息
Department of Medicine, Turku University Hospital, Turku, Finland.
出版信息
J Invasive Cardiol. 2012 Dec;24(12):631-5.
OBJECTIVES
To assess early vascular healing with endothelial progenitor cell (EPC)-capturing stents.
BACKGROUND
Endothelialization of stent struts is crucial after stenting, since delayed vascular healing predisposes to stent thrombosis. The antibody-coated Genous stent promotes rapid endothelialization by capturing circulating EPCs.
METHODS
We enrolled 20 patients who had EPC-capturing stent implanted in the left anterior descending (LAD) coronary artery. Patients underwent optical coherence tomography 30 days following the index procedure. Coronary flow reserve (CFR) was assessed in the LAD by transthoracic echocardiography at 30 days.
RESULTS
After follow-up of 31.8 ± 5.3 days, the binary stent strut coverage was 95% and the percentage of malapposed struts was 2.4%. No thrombi were detected. The mean neointimal hyperplasia (NIH) thickness was 108 ± 96 μm and the percent NIH area was 8.9 ± 7.4%. The mean CFR was 2.4 ± 0.7.
CONCLUSIONS
The EPC-capturing stent showed rapid endothelialization, low NIH area, and few malapposed struts at 30 days.
目的
评估采用捕获内皮祖细胞（EPC）支架的早期血管愈合情况。
背景
支架置入后支架小梁的内皮化至关重要，因为血管愈合延迟易导致支架内血栓形成。抗体包被的吉诺支架通过捕获循环中的EPC促进快速内皮化。
方法
我们纳入了20例在左前降支（LAD）冠状动脉植入捕获EPC支架的患者。患者在初次手术后30天接受光学相干断层扫描。在30天时通过经胸超声心动图评估LAD的冠状动脉血流储备（CFR）。
结果
随访31.8±5.3天后，支架小梁的二元覆盖率为95%，贴壁不良小梁的百分比为2.4%。未检测到血栓。平均新生内膜增生（NIH）厚度为108±96μm，NIH面积百分比为8.9±7.4%。平均CFR为2.4±0.7。
结论
捕获EPC支架在30天时显示出快速内皮化、低NIH面积和少量贴壁不良小梁。
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