Division of Experimental Medicine, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue West, Room F3-24,Montreal, Quebec, Canada.
Reproduction. 2013 Jan 24;145(2):R55-64. doi: 10.1530/REP-12-0103. Print 2013 Feb.
Successful mammalian reproduction is dependent on a receptive and nurturing uterine environment. In order to establish pregnancy in humans, the uterus must i) be adequately prepared to receive the blastocyst, ii) engage in a coordinated molecular dialog with the embryo to facilitate implantation, and iii) undergo endometrial decidualization. Although numerous factors have been implicated in these essential processes, the precise network of molecular interactions that govern receptivity, embryo implantation, and decidualization remain unclear. NODAL, a morphogen in the transforming growth factor β superfamily, is well known for its critical functions during embryogenesis; however, recent studies have demonstrated an emerging role for NODAL signaling during early mammalian reproduction. Here, we review the established data and a recent wave of new studies implicating NODAL signaling components in uterine cycling, embryo implantation, and endometrial decidualization in humans and mice.
成功的哺乳动物繁殖依赖于一个接受和滋养的子宫环境。为了在人类中建立妊娠，子宫必须：i）充分准备好接受胚泡，ii）与胚胎进行协调的分子对话，以促进着床，iii）进行子宫内膜蜕膜化。尽管有许多因素涉及这些基本过程，但调控接受、胚胎着床和蜕膜化的精确分子相互作用网络仍不清楚。NODAL 是转化生长因子 β 超家族中的一种形态发生素，它在胚胎发生过程中的关键功能是众所周知的；然而，最近的研究表明，NODAL 信号在早期哺乳动物生殖中的作用正在浮现。在这里，我们回顾了已建立的资料和最近一波新的研究，这些研究表明 NODAL 信号成分在人类和小鼠的子宫周期、胚胎着床和子宫内膜蜕膜化中起作用。
