人胃分泌物中的中性粒细胞趋化活性。
Neutrophil chemotactic activity in human gastric secretions.
作者信息
Kozol R A, Punzo A, Ribaudo R, Rossomando E F, Elgebaly S A
机构信息
Department of Surgery, University of Connecticut Health Science Center, Farmington.
出版信息
Arch Surg. 1990 Apr;125(4):454-6. doi: 10.1001/archsurg.1990.01410160040008.
To study levels of neutrophil chemotactic activity in human gastric secretions, these secretions were collected via the endoscope during elective esophagogastroduodenoscopy. Fresh samples were then prepared for the neutrophil chemotactic assay with the use of human peripheral neutrophils in modified Boyden chambers. Mean maximum chemotactic activity was 45.8% +/- 11.2% in patients with gastric inflammation compared with only 10.1% +/- 4.2% in patients with normal results of endoscopic examination. The chemotactic factors responsible for this chemotactic activity may play a role in the recruitment of neutrophils to areas of gastric mucosal injury.
为研究人类胃分泌物中中性粒细胞趋化活性水平，在择期食管胃十二指肠镜检查期间通过内窥镜收集这些分泌物。然后使用改良的博伊登小室中的人外周血中性粒细胞制备新鲜样本用于中性粒细胞趋化测定。与内镜检查结果正常的患者中仅10.1%±4.2%相比，胃炎患者的平均最大趋化活性为45.8%±11.2%。负责这种趋化活性的趋化因子可能在将中性粒细胞募集到胃黏膜损伤区域中起作用。
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