塔斯马尼亚恶魔体内主要组织相容性复合体多样性较低，这种情况早于欧洲人的定居，可能解释了其对疾病流行的易感性。
Low major histocompatibility complex diversity in the Tasmanian devil predates European settlement and may explain susceptibility to disease epidemics.
机构信息
Faculty of Veterinary Science, University of Sydney, Sydney, New South Wales 2006, Australia.
出版信息
Biol Lett. 2012 Dec 5;9(1):20120900. doi: 10.1098/rsbl.2012.0900. Print 2013 Feb 23.
Abstract
The Tasmanian devil (Sarcophilus harrisii) is at risk of extinction owing to the emergence of a contagious cancer known as devil facial tumour disease (DFTD). The emergence and spread of DFTD has been linked to low genetic diversity in the major histocompatibility complex (MHC). We examined MHC diversity in historical and ancient devils to determine whether loss of diversity is recent or predates European settlement in Australia. Our results reveal no additional diversity in historical Tasmanian samples. Mainland devils had common modern variants plus six new variants that are highly similar to existing alleles. We conclude that low MHC diversity has been a feature of devil populations since at least the Mid-Holocene and could explain their tumultuous history of population crashes.
摘要
袋獾（Sarcophilus harrisii）正面临灭绝的危险，原因是一种名为恶魔面部肿瘤病（DFTD）的传染性癌症的出现。DFTD 的出现和传播与主要组织相容性复合体（MHC）的遗传多样性低有关。我们检查了历史和古代袋獾的 MHC 多样性，以确定多样性的丧失是最近发生的还是早于欧洲人在澳大利亚的定居。我们的研究结果表明，历史上的塔斯马尼亚袋獾样本没有更多的多样性。大陆袋獾具有常见的现代变体，加上六个与现有等位基因高度相似的新变体。我们的结论是，自中全新世以来，MHC 多样性低一直是袋獾种群的一个特征，这可以解释它们种群崩溃的动荡历史。
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PLoS One. 2012;7(4):e35433. doi: 10.1371/journal.pone.0035433. Epub 2012 Apr 18.
2
Low MHC class II diversity in the Tasmanian devil (Sarcophilus harrisii).
Immunogenetics. 2012 Jul;64(7):525-33. doi: 10.1007/s00251-012-0614-4. Epub 2012 Mar 31.
3
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PLoS One. 2011;6(7):e22402. doi: 10.1371/journal.pone.0022402. Epub 2011 Jul 21.
4
Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil).
Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12348-53. doi: 10.1073/pnas.1102838108. Epub 2011 Jun 27.
5
Rapid loss of MHC class II variation in a bottlenecked population is explained by drift and loss of copy number variation.
J Evol Biol. 2011 Sep;24(9):1847-56. doi: 10.1111/j.1420-9101.2011.02311.x. Epub 2011 May 23.
6
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7
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Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16221-6. doi: 10.1073/pnas.0704580104. Epub 2007 Oct 2.
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Immunogenetics. 2007 Sep;59(9):753-60. doi: 10.1007/s00251-007-0238-2. Epub 2007 Aug 3.
9
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Aust Vet J. 2006 Oct;84(10):362-3. doi: 10.1111/j.1751-0813.2006.00032.x.
10
Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.
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