在含有溶酶体“高摄取形式”的细胞中溶酶体酒石酸敏感性酸性磷酸酶缺乏。
Lysosomal tartrate sensitive acid phosphatase deficiency in cells which contain lysosomal "high uptake forms".
作者信息
Hu P, Parenti G, Keulemans J, Hoogeveen A T
机构信息
Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands.
出版信息
Biochem Biophys Res Commun. 1990 Mar 16;167(2):520-7. doi: 10.1016/0006-291x(90)92055-5.
The catalytic and immunological properties of acid phosphatases (EC 3.1.3.2.) in different tissues were studied. It was demonstrated that high uptake forms of lysosomal enzymes like beta-galactosidase isolated from human platelets and bovine testis are mature enzymes, which have not lost their mannose-6phosphate marker. The results presented indicate that this phenomenon is related to a low activity or the complete absence of the lysosomal tartrate sensitive acid phosphatase activity in the tissues concerned.
研究了不同组织中酸性磷酸酶（EC 3.1.3.2.）的催化和免疫学特性。结果表明，从人血小板和牛睾丸中分离出的溶酶体酶（如β-半乳糖苷酶）的高摄取形式是成熟酶，它们并未失去其甘露糖-6-磷酸标记。所呈现的结果表明，这种现象与相关组织中溶酶体酒石酸敏感酸性磷酸酶活性低或完全缺乏有关。
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