Burton P B, Moniz C, Knight D E
Division of Biomedical Sciences, Kings College, London, United Kingdom.
Biochem Biophys Res Commun. 1990 Mar 30;167(3):1134-8. doi: 10.1016/0006-291x(90)90641-y.
Parathyroid hormone related peptide (PTHrP) has been implicated in the cause of the hypercalcemia associated with a number of malignant tumours. The data presented here suggests that PTHrP (in addition to its known role of mediating hypercalcemia) may be involved in the autocrine regulation of growth of some tumours. Polyclonal PTHrP antiserum almost totally inhibited the growth of a human renal cell carcinoma cell line, known to secrete PTHrP, in vitro and growth was significantly inhibited by the competitive PTH antagonist PTH (3-34)NH2.
甲状旁腺激素相关肽（PTHrP）被认为与多种恶性肿瘤相关的高钙血症的病因有关。此处呈现的数据表明，PTHrP（除了其已知的介导高钙血症的作用外）可能参与某些肿瘤生长的自分泌调节。多克隆PTHrP抗血清在体外几乎完全抑制了一种已知分泌PTHrP的人肾癌细胞系的生长，并且竞争性PTH拮抗剂PTH(3 - 34)NH2显著抑制了其生长。
