Peehl D M, Edgar M G, Cramer S D, Deftos L J
Department of Urology, Stanford University School of Medicine, Stanford, California.
Prostate. 1997 Apr 1;31(1):47-52. doi: 10.1002/(sici)1097-0045(19970401)31:1<47::aid-pros8>3.0.co;2-f.
Parathyroid hormone-related protein (PTHrP) is the primary factor responsible for humoral hypercalcemia of malignancy. The hypercalcemic actions of PTHrP occur via stimulation of renal distal tubular calcium reabsorption and increased osteoclastic bone resorption. These effects of PTHrP are thought to be mediated through a common parathyroid hormone (PTH)/PTHrP receptor. In addition to the well-established role of PTHrP in bone remodeling, PTHrP is believed to be an important mediator of cellular growth and differentiation in a number of nonbony tissues. We recently demonstrated abundant expression of PTHrP in normal and malignant human prostatic tissues, and in cultured prostatic epithelial cells.
In vitro assays were used to test growth-regulatory activity of synthetic and endogenous PTHrP peptides on normal prostatic epithelial cells.
No growth-regulatory activity could be demonstrated.
PTHrP is not an autocrine growth factor for normal prostatic epithelial cells.
甲状旁腺激素相关蛋白（PTHrP）是导致恶性肿瘤体液性高钙血症的主要因素。PTHrP的高钙血症作用是通过刺激肾远端小管对钙的重吸收以及增加破骨细胞的骨吸收来实现的。PTHrP的这些作用被认为是通过共同的甲状旁腺激素（PTH）/PTHrP受体介导的。除了在骨重塑中已确立的作用外，PTHrP还被认为是许多非骨组织中细胞生长和分化的重要介质。我们最近证明PTHrP在正常和恶性人前列腺组织以及培养的前列腺上皮细胞中大量表达。
采用体外试验检测合成的和内源性PTHrP肽对正常前列腺上皮细胞的生长调节活性。
未证明有生长调节活性。
PTHrP不是正常前列腺上皮细胞的自分泌生长因子。
