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非佛波醇酯肿瘤促进剂冈田酸不会促进仓鼠胚胎细胞的形态转化，也不会抑制其细胞间通讯。

The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cells.

作者信息

Rivedal E, Mikalsen S O, Sanner T

机构信息

Laboratory for Environmental and Occupational Cancer, Institute for Cancer Research, Montebello, Oslo, Norway.

出版信息

Biochem Biophys Res Commun. 1990 Mar 30;167(3):1302-8. doi: 10.1016/0006-291x(90)90665-a.

DOI:10.1016/0006-291x(90)90665-a
PMID:2322276
Abstract

Okadaic acid is a potent non-phorbol ester mouse skin tumor promoter. Unlike the phorbol ester tumor promoters, okadaic acid is unable to promote the induction of morphological transformation in Syrian hamster embryo cell colonies. On the contrary, okadaic acid seems to counteract the effect of phorbol esters on transformation. Also unlike phorbol ester tumor promoters, okadaic acid does not inhibit intercellular communication, neither in primary hamster embryo cells, nor in the phorbol ester sensitive cell line BPNi. Furthermore, okadaic acid has no effect on the reoccurrence of communication following removal of 12-O-tetradecanoylphorbol-13-acetate.

摘要

冈田酸是一种强效的非佛波酯类小鼠皮肤肿瘤促进剂。与佛波酯类肿瘤促进剂不同，冈田酸无法促进叙利亚仓鼠胚胎细胞集落形态转化的诱导。相反，冈田酸似乎能抵消佛波酯对转化的作用。同样与佛波酯类肿瘤促进剂不同，冈田酸在原代仓鼠胚胎细胞以及佛波酯敏感细胞系BPNi中均不抑制细胞间通讯。此外，去除12-O-十四酰佛波醇-13-乙酸酯后，冈田酸对通讯的再次出现没有影响。

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1
The non-phorbol ester tumor promoter okadaic acid does not promote morphological transformation or inhibit junctional communication in hamster embryo cells.非佛波醇酯肿瘤促进剂冈田酸不会促进仓鼠胚胎细胞的形态转化，也不会抑制其细胞间通讯。
Biochem Biophys Res Commun. 1990 Mar 30;167(3):1302-8. doi: 10.1016/0006-291x(90)90665-a.
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12-O-tetradecanoylphorbol-13-acetate-induced inhibition of gap junctional communication is differentially regulated in a transformation-sensitive Syrian hamster embryo cell line compared to early passage SHE cells.与早期传代的叙利亚仓鼠胚胎（SHE）细胞相比，在一种对转化敏感的叙利亚仓鼠胚胎细胞系中，12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯诱导的间隙连接通讯抑制受到不同的调节。
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Brief exposures of resting fibroblasts to okadaic acid stimulate DNA synthesis.将静止的成纤维细胞短暂暴露于冈田酸中可刺激DNA合成。
Cell Prolif. 1997 Jan;30(1):7-19. doi: 10.1046/j.1365-2184.1997.00065.x.