Rivedal E, Sanner T, Enomoto T, Yamasaki H
Carcinogenesis. 1985 Jun;6(6):899-902. doi: 10.1093/carcin/6.6.899.
The possible role of blocked intercellular communication in the process of cell transformation has been studied with Syrian hamster embryo cell lines which are sensitive or resistant to TPA-induced enhancement of morphological transformation. Both the TPA-sensitive (BPNi) and the TPA-resistant (83-106 and 74-100) cell lines showed gap-junctional communication when measured by a dye-transfer method. However, TPA inhibited the communication only in TPA-sensitive cells, and not in TPA-resistant cells. These results are consistent with the idea that blocked intercellular communication is involved in a late stage of cell transformation and/or expression of the transformed phenotype.
利用对佛波酯（TPA）诱导的形态转化增强敏感或抗性的叙利亚仓鼠胚胎细胞系，研究了细胞间通讯受阻在细胞转化过程中可能发挥的作用。通过染料转移法测量时，TPA敏感细胞系（BPNi）和TPA抗性细胞系（83 - 106和74 - 100）均显示出间隙连接通讯。然而，TPA仅抑制TPA敏感细胞中的通讯，而不抑制TPA抗性细胞中的通讯。这些结果与细胞间通讯受阻参与细胞转化后期和/或转化表型表达的观点一致。
