Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, P.R. China.
Curr Opin Endocrinol Diabetes Obes. 2013 Feb;20(1):22-6. doi: 10.1097/MED.0b013e32835bc368.
Description of the recent findings of the biological roles of bombesin-like peptides and their receptors in lungs.
Gastrin-releasing peptide (GRP) was involved in the airway inflammation in murine models of airway hyperreactivity. The circulating proGRP could serve as a valuable tumor marker for small-cell lung cancers, and the plasma level of proGRP is more stable compared with that of serum proGRP. Recent studies also shed light on the intracellular signaling pathways of bombesin receptor subtype-3 (BRS-3) activation in cultured human lung cancer cells.
The relevant biology of BLPs and their receptors in lung cancers and other lung diseases still remains largely unknown. With the development of several highly specific BRS-3 agonists, recent studies provided some insights into the biological effects of BRS-3 in lungs.
描述铃蟾肽样肽及其受体在肺部的生物学作用的最新发现。
胃泌素释放肽（GRP）参与了气道高反应性的小鼠模型中的气道炎症。循环前胃泌素原（proGRP）可作为小细胞肺癌的有价值的肿瘤标志物，与血清 proGRP 相比，其血浆水平更稳定。最近的研究还揭示了培养的人肺癌细胞中铃蟾肽受体亚型-3（BRS-3）激活的细胞内信号通路。
BLPs 及其受体在肺癌和其他肺部疾病中的相关生物学特性在很大程度上仍不清楚。随着几种高特异性 BRS-3 激动剂的发展，最近的研究为 BRS-3 在肺部的生物学效应提供了一些见解。
