Lindsay R M, Baty J D
Department of Biochemical Medicine (University of Dundee), Ninewells Hospital and Medical School, U.K.
Biochem Pharmacol. 1990 Apr 1;39(7):1193-7. doi: 10.1016/0006-2952(90)90262-j.
Induction of experimental diabetes using streptozotocin significantly reduced the extent of sulphamethazine acetylation by Sprague-Dawley rats. This treatment did not significantly change the total amount of sulphonomide excreted in the urine. The in vitro blood N-acetyltransferase activity of rats treated with streptozotocin was significantly higher than that of untreated animals. Increasing the in vitro glucose concentration of blood samples from both groups significantly increased the amount of acetylsulphamethazine produced.
