着床机制：成功妊娠的策略。
Mechanisms of implantation: strategies for successful pregnancy.
机构信息
Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
出版信息
Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012.
Abstract
Physiological and molecular processes initiated during implantation for pregnancy success are complex but highly organized. This review primarily highlights adverse ripple effects arising from defects during the peri-implantation period that perpetuate throughout pregnancy. These defects are reflected in aberrations in embryo spacing, decidualization, placentation and intrauterine embryonic growth, manifesting in preeclampsia, miscarriages and/or preterm birth. Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization.
摘要
胚胎着床期为妊娠成功启动的生理和分子进程十分复杂，但又高度有序。本综述主要强调了胚胎着床期缺陷引起的不良连锁反应对妊娠的持续影响。这些缺陷反映在胚胎间距、蜕膜化、胎盘形成和子宫内胚胎生长的异常上，表现为子痫前期、流产和/或早产。了解协调成功着床和蜕膜化策略的分子信号网络，可能有助于改善自然妊娠和体外受精妊娠的结局。
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本文引用的文献
1
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Dev Cell. 2012 Oct 16;23(4):858-65. doi: 10.1016/j.devcel.2012.09.002.
2
Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict.胎盘哺乳动物的胸腺外生成调节性 T 细胞可减轻母婴冲突。
Cell. 2012 Jul 6;150(1):29-38. doi: 10.1016/j.cell.2012.05.031.
3
Activation of the epithelial Na+ channel triggers prostaglandin E₂ release and production required for embryo implantation.上皮钠通道的激活触发了前列腺素 E₂ 的释放和胚胎植入所必需的产生。
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4
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Nat Rev Genet. 2012 Jun 18;13(7):493-504. doi: 10.1038/nrg3245.
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6
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7
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