Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012.
Physiological and molecular processes initiated during implantation for pregnancy success are complex but highly organized. This review primarily highlights adverse ripple effects arising from defects during the peri-implantation period that perpetuate throughout pregnancy. These defects are reflected in aberrations in embryo spacing, decidualization, placentation and intrauterine embryonic growth, manifesting in preeclampsia, miscarriages and/or preterm birth. Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization.
胚胎着床期为妊娠成功启动的生理和分子进程十分复杂，但又高度有序。本综述主要强调了胚胎着床期缺陷引起的不良连锁反应对妊娠的持续影响。这些缺陷反映在胚胎间距、蜕膜化、胎盘形成和子宫内胚胎生长的异常上，表现为子痫前期、流产和/或早产。了解协调成功着床和蜕膜化策略的分子信号网络，可能有助于改善自然妊娠和体外受精妊娠的结局。
