Yang Yan, Zheng Zhanhong
College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Biomolecules. 2025 Jul 31;15(8):1102. doi: 10.3390/biom15081102.
This review examines the regulatory role of m6A methylation modification in embryo implantation, focusing specifically on its impact on uterine receptivity and decidualization. It offers a comprehensive examination of the essential theoretical research on m6A methylation, clarifying its molecular mechanisms and roles in uterine receptivity and decidualization. Furthermore, this review examined the effects of m6A methylation on endometrial-related diseases and early embryonic development. It synthesizes early findings and recent advancements in m6A methylation studies. Through a comprehensive analysis of relevant studies, this review offers novel insights into the molecular mechanisms underlying embryo implantation and suggests potential strategies for assisted reproductive technologies and the treatment of related disorders, thereby serving as a comprehensive reference for future research in this domain.
本综述探讨了m6A甲基化修饰在胚胎着床中的调控作用,特别关注其对子宫容受性和蜕膜化的影响。它全面审视了关于m6A甲基化的重要理论研究,阐明了其在子宫容受性和蜕膜化中的分子机制及作用。此外,本综述研究了m6A甲基化对子宫内膜相关疾病和早期胚胎发育的影响。它综合了m6A甲基化研究的早期发现和最新进展。通过对相关研究的全面分析,本综述为胚胎着床的分子机制提供了新的见解,并提出了辅助生殖技术及相关疾病治疗的潜在策略,从而为该领域未来的研究提供了全面的参考。