Ruck P, Pfisterer E M, Kaiserling E
Abteilung für Spezielle Histo- und Zytopathologie, Institut für Pathologie, Universität Tübingen.
Laryngorhinootologie. 1990 Feb;69(2):74-6. doi: 10.1055/s-2007-998146.
We describe the unusual case of a carcinoid tumour of the middle ear occurring in a woman of 50 years of age. The tumour exhibited both glandular and neuroendocrine differentiation. Immunohistochemical demonstration of chromogranin A is of particular diagnostic importance as evidence of neuroendocrine differentiation. The morphological spectrum of the middle ear tumours with neuroendocrine and/or glandular differentiation reported in the literature is discussed in detail. These tumours are arranged schematically according to the degree of glandular and of neuroendocrine differentiation, and are compared with the tumours of other regions. The data in the literature do not allow unequivocal assertions concerning the prognosis of carcinoid tumours of the middle ear to be made, and very diverse therapeutic measures have been employed in the reported cases. In our case there is no evidence of recurrence six months after local tumour excision.
我们描述了一例发生在一名50岁女性身上的中耳类癌肿瘤的罕见病例。该肿瘤表现出腺性和神经内分泌分化。嗜铬粒蛋白A的免疫组织化学证明作为神经内分泌分化的证据具有特别的诊断重要性。详细讨论了文献中报道的具有神经内分泌和/或腺性分化的中耳肿瘤的形态学谱。这些肿瘤根据腺性和神经内分泌分化程度进行了示意性排列，并与其他区域的肿瘤进行了比较。文献中的数据不允许对中耳类癌肿瘤的预后做出明确断言，并且在报道的病例中采用了非常多样的治疗措施。在我们的病例中，局部肿瘤切除六个月后没有复发迹象。
