Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.
Nanoscale. 2013 Feb 21;5(4):1369-84. doi: 10.1039/c2nr33239f.
Trivalent lanthanide (Ln(3+))-doped luminescent inorganic nanoparticles (NPs), characterized by long-lived luminescence, large Stokes and/or anti-Stokes shifts, narrow emission bands and high photochemical stability, are considered to be promising candidates as luminescent bioprobes in biomedicine and biotechnology. In this feature article, we provide a brief overview of the most recent advances in Ln(3+)-doped luminescent inorganic NPs as sensors, which covers from their chemical and physical fundamentals to biodetection, such as controlled synthesis methodology, surface modification chemistry, optical physics, and their promising applications in diverse bioassays, with an emphasis on heterogeneous and homogeneous in vitro biodetection. Finally, some of the most important emerging trends and future efforts toward this active research field are also proposed.
三价镧系（Ln(3+))掺杂发光无机纳米粒子（NPs）具有长寿命发光、大斯托克斯和/或反斯托克斯位移、窄发射带和高光化学稳定性等特点，被认为是生物医学和生物技术中作为发光生物探针的有前途的候选者。在这篇专题文章中，我们简要概述了 Ln(3+)-掺杂发光无机 NPs 作为传感器的最新进展，涵盖了从化学和物理基础到生物检测，如控制合成方法、表面修饰化学、光学物理，以及它们在各种生物测定中的有前途的应用，重点介绍了异质和同质体外生物检测。最后，还提出了该活跃研究领域的一些最重要的新兴趋势和未来努力方向。
