Li Xingjun, Lu Shan, Tu Datao, Zheng Wei, Chen Xueyuan
CAS Key Laboratory of Design and Assembly of Functional Nanostructures, State Key Laboratory of Structural Chemistry, and Fujian Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.
Nanoscale. 2020 Jul 23;12(28):15021-15035. doi: 10.1039/d0nr03373a.
Metal-organic frameworks (MOFs), a unique type of porous material characterized by high porosity, large internal surface area and remarkable structural tunability, have emerged as very attractive functional materials for a variety of applications. As a promising subclass of MOFs, lanthanide metal-organic frameworks (Ln-MOFs) integrate the unique advantages of MOFs and the intrinsic features of lanthanide ions, such as sharp emission bands, long luminescent lifetimes, large Stokes shifts, high color purity and high resistance to photobleaching. In this minireview, we provide a brief overview of the most recent advances in luminescent Ln-MOF nanoprobes, which covers from their chemical and physical fundamentals to bioapplications, including their synthetic strategies, optical properties and promising bioapplications in biodetection, bioimaging and therapy. Finally, some of the most important emerging trends and future efforts toward this rapidly evolving field are also envisioned.
金属有机框架材料（MOFs）是一类独特的多孔材料，具有高孔隙率、大的内表面积和显著的结构可调控性，已成为极具吸引力的功能材料，可用于多种应用。作为MOFs中有前景的一个子类，镧系金属有机框架材料（Ln-MOFs）整合了MOFs的独特优势和镧系离子的固有特性，如尖锐的发射带、长的发光寿命、大的斯托克斯位移、高色纯度和高抗光漂白性。在这篇综述中，我们简要概述了发光Ln-MOF纳米探针的最新进展，内容涵盖其化学和物理基础以及生物应用，包括其合成策略、光学性质以及在生物检测、生物成像和治疗方面有前景的生物应用。最后，还展望了这一快速发展领域一些最重要的新兴趋势和未来努力方向。
