Smith D K, Poon M C, Flint A
Med Pediatr Oncol. 1979;7(3):263-7. doi: 10.1002/mpo.2950070312.
A case of inflammatory fibrous histiocytoma arising in soft tissue near the sacrum is presented. The patient's mode of presentation, clinical course, and tumor histology were typical of this disease. The tumor was inoperable, and radiotherapy combined with doxorubicin, cyclophosphamide, and intermediate-dose oral methotrexate produced a dramatic complete response lasting over 27 months. Favorable results with nonsurgical therapy have not previously been reported for this disease. The gratifying result obtained, although of relatively short duration to date, indicates that combined modality therapy may provide significant back-up to aggressive surgery. The use of these agents in an adjuvant setting merits study.
本文报告了一例发生于骶骨附近软组织的炎性纤维组织细胞瘤。患者的临床表现、临床病程及肿瘤组织学表现均符合该病的典型特征。该肿瘤无法手术切除，放疗联合阿霉素、环磷酰胺及中剂量口服甲氨蝶呤治疗后出现显著的完全缓解，持续时间超过27个月。此前尚未有关于该病非手术治疗取得良好效果的报道。尽管目前取得的满意疗效持续时间相对较短，但这表明综合治疗可能为积极的手术治疗提供重要支持。在辅助治疗中使用这些药物值得研究。
