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1
Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis.鱼藤素，一种天然的鱼藤酮类化合物，通过诱导凋亡在体外抑制小鼠骨髓瘤细胞生长。
Oncol Lett. 2012 Oct;4(4):677-681. doi: 10.3892/ol.2012.790. Epub 2012 Jul 6.
2
Antitumor effects of deguelin on H460 human lung cancer cells in vitro and in vivo: Roles of apoptotic cell death and H460 tumor xenografts model.鱼藤素对人H460肺癌细胞的体内外抗肿瘤作用：凋亡性细胞死亡及H460肿瘤异种移植模型的作用
Environ Toxicol. 2017 Jan;32(1):84-98. doi: 10.1002/tox.22214. Epub 2015 Nov 23.
3
Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice.地榆苷，一种 Akt 抑制剂，可下调 NF-κB 信号通路并诱导结肠癌细胞凋亡，抑制小鼠肿瘤生长。
Dig Dis Sci. 2012 Nov;57(11):2873-82. doi: 10.1007/s10620-012-2237-x. Epub 2012 May 24.
4
Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase-3 β/β-catenin pathway.去氢骆驼蓬碱通过靶向糖原合成激酶-3β/β-连环蛋白通路抑制人前列腺癌细胞增殖和迁移的作用研究
Int J Cancer. 2011 Dec 15;129(12):2916-27. doi: 10.1002/ijc.25949. Epub 2011 Apr 7.
5
Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway.地榆苷通过诱导细胞凋亡和 G2/M 细胞周期阻滞抑制人多发性骨髓瘤细胞的增殖：涉及 Akt 和 p38 MAPK 信号通路。
Acta Pharm. 2024 Mar 30;74(1):101-115. doi: 10.2478/acph-2024-0003. Print 2024 Mar 1.
6
Deguelin induces the apoptosis of lung cancer cells through regulating a ROS driven Akt pathway.德古醇通过调节活性氧簇（ROS）驱动的 Akt 通路诱导肺癌细胞凋亡。
Cancer Cell Int. 2015 Feb 25;15:25. doi: 10.1186/s12935-015-0166-4. eCollection 2015.
7
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells.鱼藤素对人支气管上皮癌前细胞中磷脂酰肌醇3-激酶/蛋白激酶B信号通路及细胞凋亡的影响
J Natl Cancer Inst. 2003 Feb 19;95(4):291-302. doi: 10.1093/jnci/95.4.291.
8
Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer.地榆苷促进胃癌细胞凋亡并抑制血管生成。
Oncol Rep. 2010 Oct;24(4):957-63. doi: 10.3892/or.2010.957.
9
Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway.鱼藤素通过激活p38丝裂原活化蛋白激酶（MAPK）信号通路诱导大肠癌细胞凋亡。
Cancer Manag Res. 2018 Dec 20;11:95-105. doi: 10.2147/CMAR.S169476. eCollection 2019.
10
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies.地榆苷通过靶向多种致癌信号通路来治疗人类恶性肿瘤。
Pharmacol Res. 2021 Apr;166:105487. doi: 10.1016/j.phrs.2021.105487. Epub 2021 Feb 11.

引用本文的文献

1
BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells.促凋亡蛋白BAD在鱼藤素和经小干扰RNA处理的HeLa细胞中逃避细胞外信号调节激酶/核糖体S6激酶磷酸化作用。
PLoS One. 2016 Jan 8;11(1):e0145780. doi: 10.1371/journal.pone.0145780. eCollection 2016.
2
Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts.通过对部分纯化的天然产物提取物进行高通量筛选鉴定出的去甲豆素，是NF1缺陷型星形细胞瘤细胞生长的天然产物调节剂。
J Nat Prod. 2015 Nov 25;78(11):2776-81. doi: 10.1021/acs.jnatprod.5b00753. Epub 2015 Oct 15.
3
Regulatory effects of deguelin on proliferation and cell cycle of Raji cells.鱼藤素对Raji细胞增殖和细胞周期的调控作用
J Huazhong Univ Sci Technolog Med Sci. 2013 Aug;33(4):491-495. doi: 10.1007/s11596-013-1147-2. Epub 2013 Aug 1.
4
Cell survival and metastasis regulation by Akt signaling in colorectal cancer.Akt 信号对结直肠癌中细胞存活和转移的调节。
Cell Signal. 2013 Aug;25(8):1711-9. doi: 10.1016/j.cellsig.2013.03.025. Epub 2013 Apr 18.

本文引用的文献

1
Epidemiology of multiple myeloma.多发性骨髓瘤的流行病学
Recent Results Cancer Res. 2011;183:25-35. doi: 10.1007/978-3-540-85772-3_2.
2
Multiple myeloma.多发性骨髓瘤
N Engl J Med. 2011 Mar 17;364(11):1046-60. doi: 10.1056/NEJMra1011442.
3
Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer.地榆苷促进胃癌细胞凋亡并抑制血管生成。
Oncol Rep. 2010 Oct;24(4):957-63. doi: 10.3892/or.2010.957.
4
Molecular mechanism of apoptosis induction by resveratrol, a natural cancer chemopreventive agent.天然癌症化学预防剂白藜芦醇诱导细胞凋亡的分子机制。
Int J Vitam Nutr Res. 2008 Jan;78(1):3-8. doi: 10.1024/0300-9831.78.1.3.
5
Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis.鱼藤素通过抗血管生成和诱导凋亡抑制人肝癌细胞。
Oncol Rep. 2008 Jul;20(1):129-34.
6
Targeting Akt in cancer therapy.癌症治疗中针对Akt的研究
Anticancer Drugs. 2007 Sep;18(8):861-74. doi: 10.1097/CAD.0b013e3280cc2c6f.
7
Deguelin inhibits expression of IkappaBalpha protein and induces apoptosis of B-CLL cells in vitro.鱼藤素在体外抑制IκBα蛋白表达并诱导B-慢性淋巴细胞白血病细胞凋亡。
Leukemia. 2007 Aug;21(8):1610-8. doi: 10.1038/sj.leu.2404788. Epub 2007 Jun 14.
8
Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.厚朴酚，一种天然的联苯，通过诱导细胞凋亡和细胞周期停滞来抑制乳腺癌的体外和体内生长。
Int J Oncol. 2007 Jun;30(6):1529-37.
9
Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells.鱼藤素下调凋亡抑制蛋白可选择性诱导乳腺癌细胞凋亡。
Mol Pharmacol. 2007 Jan;71(1):101-11. doi: 10.1124/mol.106.027367. Epub 2006 Oct 11.
10
Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IkappaB kinase/nuclear factor-kappaB pathway.天然和合成环戊烯酮诱导雌激素受体阴性乳腺癌细胞凋亡：IκB激酶/核因子-κB通路的作用
Mol Pharmacol. 2006 Nov;70(5):1812-21. doi: 10.1124/mol.106.025759. Epub 2006 Aug 14.

鱼藤素，一种天然的鱼藤酮类化合物，通过诱导凋亡在体外抑制小鼠骨髓瘤细胞生长。

Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis.

作者信息

Li Zhengguang, Wu Jun, Wu Changping, Jiang Jingting, Zheng Xiao, Xu Bin, Li Min

机构信息

Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, P.R. China.

出版信息

Oncol Lett. 2012 Oct;4(4):677-681. doi: 10.3892/ol.2012.790. Epub 2012 Jul 6.

DOI:10.3892/ol.2012.790
PMID:23226790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3506627/
Abstract

Deguelin is a naturally occurring rotenoid with strong cancer chemopreventive and antitumor activities. In the present study, we investigated the antitumor activity of deguelin against MPC-11 murine myeloma cells and the possible mechanism of action in vitro. Our results revealed that deguelin inhibited the proliferation of MPC-11 cells in a concentration- and time-dependent manner and caused the apoptotic death of MPC-11 cells. Following exposure to deguelin, the phosphorylation of Akt was decreased. The inhibition of cell growth may be associated with decreased levels of phosphorylated Akt. Deguelin-induced apoptosis was characterized by the upregulation of Bax, downregulation of Bcl-2 and activation of caspase-3. In conclusion, deguelin inhibits murine myeloma cell proliferation by inducing apoptosis via regulation of the Bax/Bcl-2 ratio and by inhibition of the activation of Akt. Its potential as an anticancer agent against multiple myeloma warrants further investigation.

摘要

鱼藤素是一种天然存在的鱼藤酮类化合物，具有很强的癌症化学预防和抗肿瘤活性。在本研究中，我们研究了鱼藤素对MPC - 11小鼠骨髓瘤细胞的抗肿瘤活性及其体外可能的作用机制。我们的结果表明，鱼藤素以浓度和时间依赖性方式抑制MPC - 11细胞的增殖，并导致MPC - 11细胞凋亡死亡。暴露于鱼藤素后，Akt的磷酸化水平降低。细胞生长的抑制可能与磷酸化Akt水平的降低有关。鱼藤素诱导的凋亡表现为Bax上调、Bcl - 2下调和caspase - 3激活。总之，鱼藤素通过调节Bax/Bcl - 2比值诱导凋亡并抑制Akt激活来抑制小鼠骨髓瘤细胞增殖。其作为抗多发性骨髓瘤抗癌剂的潜力值得进一步研究。