• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

天然癌症化学预防剂白藜芦醇诱导细胞凋亡的分子机制。

Molecular mechanism of apoptosis induction by resveratrol, a natural cancer chemopreventive agent.

作者信息

Fan Enguo, Jiang Sha, Zhang Lijuan, Bai Yuhua

机构信息

College of Life Sciences, Nankai University, Tian Jin, China.

出版信息

Int J Vitam Nutr Res. 2008 Jan;78(1):3-8. doi: 10.1024/0300-9831.78.1.3.

DOI:10.1024/0300-9831.78.1.3
PMID:18654947
Abstract

In efforts to identify naturally occurring compounds that act as protective agents, resveratrol, a phytoalexin existing in wine, has attracted much interest because of its diverse pharmacological characteristics. Considering that apoptosis induction is the most potent defense approach for cancer treatment, we have tried to summarize our present understanding of apoptosis induction by resveratrol based on the two major apoptosis pathways.

摘要

为了确定具有保护作用的天然化合物,白藜芦醇这种存在于葡萄酒中的植物抗毒素因其多样的药理特性而备受关注。鉴于诱导细胞凋亡是癌症治疗中最有效的防御方法,我们试图基于两种主要的细胞凋亡途径,总结目前我们对白藜芦醇诱导细胞凋亡的认识。

相似文献

1
Molecular mechanism of apoptosis induction by resveratrol, a natural cancer chemopreventive agent.天然癌症化学预防剂白藜芦醇诱导细胞凋亡的分子机制。
Int J Vitam Nutr Res. 2008 Jan;78(1):3-8. doi: 10.1024/0300-9831.78.1.3.
2
Cancer chemoprevention - selected molecular mechanisms.癌症化学预防——选定的分子机制
Postepy Hig Med Dosw (Online). 2017 Mar 2;71(0):149-161. doi: 10.5604/01.3001.0010.3799.
3
Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in carcinogenesis.白藜芦醇及其类似物在癌症发生过程中的化学预防作用的分子机制。
Mol Nutr Food Res. 2005 May;49(5):452-61. doi: 10.1002/mnfr.200400081.
4
Resveratrol and cellular mechanisms of cancer prevention.白藜芦醇与癌症预防的细胞机制。
Ann N Y Acad Sci. 2011 Jan;1215:1-8. doi: 10.1111/j.1749-6632.2010.05870.x.
5
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.白藜芦醇介导的二乙基亚硝胺引发的肝癌化学预防:抑制细胞增殖和诱导细胞凋亡。
Chem Biol Interact. 2009 May 15;179(2-3):131-44. doi: 10.1016/j.cbi.2008.11.015. Epub 2008 Nov 27.
6
Resveratrol and chemoprevention.白藜芦醇与化学预防
Cancer Lett. 2009 Oct 18;284(1):1-6. doi: 10.1016/j.canlet.2009.01.041. Epub 2009 Mar 3.
7
Resveratrol and breast cancer chemoprevention: molecular mechanisms.白藜芦醇与乳腺癌化学预防:分子机制
Mol Nutr Food Res. 2005 May;49(5):462-71. doi: 10.1002/mnfr.200400094.
8
Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives.白藜芦醇的癌症化学预防和治疗潜力:机制视角
Cancer Lett. 2008 Oct 8;269(2):243-61. doi: 10.1016/j.canlet.2008.03.057. Epub 2008 Jun 11.
9
Molecular basis of chemoprevention by resveratrol: NF-kappaB and AP-1 as potential targets.白藜芦醇化学预防的分子基础:NF-κB和AP-1作为潜在靶点
Mutat Res. 2004 Nov 2;555(1-2):65-80. doi: 10.1016/j.mrfmmm.2004.05.019.
10
Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells.在白藜芦醇对肝癌细胞的化学预防作用过程中,细胞周期蛋白D1的下调与p38丝裂原活化蛋白激酶、Akt/蛋白激酶B和p21活化激酶1水平的降低有关。
Exp Toxicol Pathol. 2011 Jan;63(1-2):167-73. doi: 10.1016/j.etp.2009.11.005. Epub 2010 Feb 4.

引用本文的文献

1
A Meroterpenoid from Tibetan Medicine Induces Lung Cancer Cells Apoptosis through ROS-Mediated Inactivation of the AKT Pathway.藏药来源的倍半萜通过 ROS 介导的 AKT 通路失活诱导肺癌细胞凋亡。
Molecules. 2023 Feb 17;28(4):1939. doi: 10.3390/molecules28041939.
2
Effect of methoxy stilbenes-analogs of resveratrol-on the viability and induction of cell cycle arrest and apoptosis in human myeloid leukemia cells.甲氧基二苯乙烯类似物-白藜芦醇对人髓系白血病细胞活力及诱导细胞周期阻滞和凋亡的影响。
Mol Cell Biochem. 2020 Nov;474(1-2):113-123. doi: 10.1007/s11010-020-03837-0. Epub 2020 Jul 31.
3
Usefulness of resveratrol supplementation in decreasing cardiometabolic risk factors comparing subjects with metabolic syndrome and healthy subjects with or without obesity: meta-analysis using multinational, randomised, controlled trials.
比较患有代谢综合征的受试者与有或无肥胖的健康受试者时,补充白藜芦醇在降低心血管代谢危险因素方面的效用:使用多国随机对照试验的荟萃分析
Arch Med Sci Atheroscler Dis. 2020 May 30;5:e98-e111. doi: 10.5114/amsad.2020.95884. eCollection 2020.
4
Cellular and Molecular Targets of Resveratrol on Lymphoma and Leukemia Cells.白藜芦醇对淋巴瘤和白血病细胞的细胞及分子靶点
Molecules. 2017 May 27;22(6):885. doi: 10.3390/molecules22060885.
5
Resveratrol: A Focus on Several Neurodegenerative Diseases.白藜芦醇:聚焦几种神经退行性疾病
Oxid Med Cell Longev. 2015;2015:392169. doi: 10.1155/2015/392169. Epub 2015 Jun 9.
6
Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis.鱼藤素,一种天然的鱼藤酮类化合物,通过诱导凋亡在体外抑制小鼠骨髓瘤细胞生长。
Oncol Lett. 2012 Oct;4(4):677-681. doi: 10.3892/ol.2012.790. Epub 2012 Jul 6.
7
The anticancer effects of resveratrol: modulation of transcription factors.白藜芦醇的抗癌作用:转录因子的调节。
Nutr Cancer. 2012;64(4):493-502. doi: 10.1080/01635581.2012.667862. Epub 2012 Apr 6.
8
Chinese herbal medicine in the treatment of nonalcoholic fatty liver disease.中草药治疗非酒精性脂肪性肝病。
Chin J Integr Med. 2012 Feb;18(2):152-60. doi: 10.1007/s11655-012-0993-2. Epub 2012 Feb 5.
9
Resveratrol-induced apoptosis is mediated by early growth response-1, Krüppel-like factor 4, and activating transcription factor 3.白藜芦醇诱导的细胞凋亡是由早期生长反应因子-1、Krüppel 样因子 4 和激活转录因子 3 介导的。
Cancer Prev Res (Phila). 2011 Jan;4(1):116-27. doi: 10.1158/1940-6207.CAPR-10-0218.
10
Sirt1's complex roles in neuroprotection.Sirt1 在神经保护中的复杂作用。
Cell Mol Neurobiol. 2009 Dec;29(8):1093-103. doi: 10.1007/s10571-009-9414-2.