Wolf Ido, O'Kelly James, Wakimoto Naoki, Nguyen Anh, Amblard Franck, Karlan Beth Y, Arbiser Jack L, Koeffler H Phillip
Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, CA, USA.
Int J Oncol. 2007 Jun;30(6):1529-37.
Honokiol (HNK), a naturally occurring biphenyl, possesses potent antineoplastic and antiangiogenic properties. We investigated the in vitro and in vivo activity of HNK against breast cancer. HNK exhibited potent anti-proliferative activity against breast cancer cell lines and enhanced the activity of other drugs used for the treatment of breast cancer. In vivo, HNK was highly effective against breast cancer in nude mice. We identified two different effects of HNK on breast cancer cells: cell cycle inhibition, observed at lower doses of HNK, and induction of apoptosis, observed at higher doses of the compound. Our data suggest that HNK is a systemically available, non-toxic inhibitor of breast cancer growth and should be examined for clinical applications.
厚朴酚（HNK）是一种天然存在的联苯，具有强大的抗肿瘤和抗血管生成特性。我们研究了HNK对乳腺癌的体外和体内活性。HNK对乳腺癌细胞系表现出强大的抗增殖活性，并增强了用于治疗乳腺癌的其他药物的活性。在体内，HNK对裸鼠乳腺癌具有高度疗效。我们确定了HNK对乳腺癌细胞的两种不同作用：在较低剂量的HNK下观察到细胞周期抑制，在较高剂量的该化合物下观察到细胞凋亡诱导。我们的数据表明，HNK是一种全身可用、无毒的乳腺癌生长抑制剂，应进行临床应用研究。
