Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, U.S.A.
Pain Pract. 2013 Jul;13(6):440-50. doi: 10.1111/papr.12011. Epub 2012 Dec 10.
Our study surveyed physician members of 3 American pain societies to determine prescription patterns and whether these practices reflect current expert opinion.
We sent 3 mailings to 2938 physicians from January 2010 to January 2011. The questionnaire contained 49 questions on topics related to opioids, antidepressants, anticonvulsants, and preferences for the different pain syndromes.
A total of 474 physicians responded, representing a 16% return. Seventy-two percent ask patients to sign an opioid agreement, 59% order random urine drug testing, 13% wait until the dose of methadone is between 100 and 150 mg before converting the drug to another opioid, and 85% do not think there is a maximum dose of opioids with respect to driving. Most responders prescribe codeine to Caucasians and Asians. While 42% stated that the maximum daily dose of acetaminophen is 3000 mg, 75% would decrease the dose in patients who are moderate or heavy drinkers. Fifty-four percent do not order an ECG at all when prescribing tricyclic antidepressants.
The responses pertaining to opioid agreements, urine drug testing, acetaminophen, and treatment for neuropathic pain are reassuring in that they prevent misuse and abuse of opioids, prevent acetaminophen-induced hepatotoxicity, and reflect evidence-based treatments. However, we identified gaps in knowledge, including the prescription of codeine in certain populations and the use of electrocardiogram in patients on antidepressants. Further education of physicians who treat chronic pain pharmacologically is warranted.
我们对 3 个美国疼痛学会的医师会员进行了调查,以确定他们的处方模式,以及这些做法是否反映了当前的专家意见。
我们于 2010 年 1 月至 2011 年 1 月期间向 2938 名医生发送了 3 次邮件。问卷包含了 49 个与阿片类药物、抗抑郁药、抗惊厥药以及不同疼痛综合征的治疗偏好相关的问题。
共有 474 名医生做出了回应,回应率为 16%。72%的医生要求患者签署阿片类药物使用协议,59%的医生会进行随机尿液药物检测,13%的医生会等到美沙酮剂量在 100-150mg 之间时再将其转换为其他阿片类药物,85%的医生认为在开车方面阿片类药物没有最大剂量。大多数应答者会给白人和亚洲人开可待因。虽然 42%的医生表示对乙酰氨基酚的最大日剂量为 3000mg,但 75%的医生会在患者是中度或重度饮酒者时减少剂量。54%的医生在开三环类抗抑郁药时根本不会做心电图。
在阿片类药物使用协议、尿液药物检测、对乙酰氨基酚和治疗神经病理性疼痛方面的回答令人欣慰,因为它们可以防止阿片类药物的误用和滥用,防止对乙酰氨基酚引起的肝毒性,并反映了基于证据的治疗方法。然而,我们发现了一些知识上的差距,包括在某些人群中开可待因的处方和在服用抗抑郁药的患者中使用心电图。有必要对治疗慢性疼痛的医生进行进一步的药理学教育。