年龄相关的胆碱能药物对两种近交系小鼠镇痛作用的影响。

Age-related cholinergic drug effects on analgesia in two inbred strains of mice.

作者信息

Fagioli S, Consorti D, Pavone F

机构信息

Dipartimento di Genetica e Biologia Molecolare, Università La Sapienza, Rome, Italy.

出版信息

Brain Res. 1990 Feb 26;510(1):150-3. doi: 10.1016/0006-8993(90)90743-u.

DOI:10.1016/0006-8993(90)90743-u

PMID:2322840

Abstract

The two inbred strains of mice C57BL/6 and DBA/2 are characterized by a different behavioral reactivity to cholinergic agents during development. The present experiment revealed that the strain-dependent differences in cholinergic-mediated analgesia during development disappeared during adult life. In fact, oxotremorine administration (0.0025 and 0.005 mg/kg) exerted the same analgesic effect in both strains at 6 months of age, in contrast with the finding of the lack of any effect of the drug in C57 mice at two months of age in comparison with DBA.

摘要

两种近交系小鼠C57BL/6和DBA/2在发育过程中对胆碱能药物具有不同的行为反应性。本实验表明，发育过程中胆碱能介导的镇痛作用的品系依赖性差异在成年期消失。事实上，给予氧化震颤素（0.0025和0.005mg/kg）在6月龄时对两个品系都产生相同的镇痛效果，这与两个月龄时该药物对C57小鼠无任何作用而对DBA小鼠有作用的结果形成对比。