两株小鼠中胆碱能药物反应的年龄依赖性差异。
Age-dependent differences in cholinergic drug response in two strains of mice.
作者信息
Castellano C, Oliverio A, Schwab C, Brueckner G, Biesold D
机构信息
Istituto di Psicobiologia e Psicofarmacologia del CNR, Rome, Italy.
出版信息
Neurosci Lett. 1988 Feb 3;84(3):335-8. doi: 10.1016/0304-3940(88)90531-9.
PMID:3352959
Abstract
The behavioral effects of nicotine and oxotremorine were assessed in two strains of mice, C57BL/6 (C57) and DBA/2 (DBA), differing in the ontogeny of forebrain cholinergic structures. Both nicotine and oxotremorine depressed to a higher extent the behavior of DBA mice starting at day 45 of postnatal life.
摘要
在两种品系的小鼠C57BL/6（C57）和DBA/2（DBA）中评估了尼古丁和氧化震颤素的行为效应，这两种品系在前脑胆碱能结构的个体发生上存在差异。从出生后第45天开始，尼古丁和氧化震颤素都更强烈地抑制了DBA小鼠的行为。
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