新生期用谷氨酸钠处理的大鼠特定下丘脑核团中的神经肽Y

Neuropeptide Y in the specific hypothalamic nuclei of rats treated neonatally with monosodium glutamate.

作者信息

Abe M, Saito M, Shimazu T

机构信息

Department of Medical Biochemistry, School of Medicine, Ehime University, Japan.

出版信息

Brain Res Bull. 1990 Feb;24(2):289-91. doi: 10.1016/0361-9230(90)90218-o.

DOI:10.1016/0361-9230(90)90218-o

PMID:2322864

Abstract

Neuropeptide Y (NPY) concentration was determined by radioimmunoassay in selected hypothalamic regions microdissected from fresh brain slices of rats treated neonatally with monosodium glutamate (MSG). Fourteen weeks after MSG treatment, significant decreases in NPY concentration were found in the paraventricular nucleus (PVN) and arcuate nucleus (ARH), while there was no appreciable change in the ventromedial nucleus (VMH) and lateral area (LH). The decrease in NPY in the ARH-PVN system may contribute to the endocrine and metabolic disturbances seen in MSG-treated animals.

摘要

采用放射免疫分析法测定了从新生期用谷氨酸钠（MSG）处理的大鼠新鲜脑片中显微切割出的特定下丘脑区域的神经肽Y（NPY）浓度。MSG处理14周后，室旁核（PVN）和弓状核（ARH）中的NPY浓度显著降低，而腹内侧核（VMH）和外侧区（LH）没有明显变化。ARH-PVN系统中NPY的减少可能导致了MSG处理动物出现的内分泌和代谢紊乱。