Kagotani Y, Hashimoto T, Tsuruo Y, Kawano H, Daikoku S, Chihara K
Department of Anatomy, School of Medicine, University of Tokushima, Japan.
Int J Dev Neurosci. 1989;7(4):359-74. doi: 10.1016/0736-5748(89)90057-9.
In the rat hypothalamus, neuropeptide Y-containing neurons first appeared on day 14.5 of gestation in the arcuate nucleus and in the dorsolateral hypothalamic area. Until birth neuropeptide Y-containing cell bodies increased in number in the arcuate, dorsomedial-lateral and paraventricular nuclei, but disappeared thereafter, but some cells remaining in the arcuate nucleus. In animals treated neonatally with monosodium L-glutamate to destroy the arcuate nucleus, neuropeptide Y-immunoreactivity became evident in many cells scattered in the magnocellular paraventricular and dorsomedial-lateral hypothalamic nuclei on day 16 but not on days 60 and 12. These neuropeptide Y-immunoreactive neurons which appeared in the paraventricular nucleus were also vasopressin-positive. Neuropeptide Y fibers, on the contrary, remarkably diminished in number on day 16, particularly in the paraventricular and dorsomedial-lateral nuclei, and the medial preoptic area, but made a considerable recovery on days 60 and 120. Hence it is probable that, in normal ontogenetic progress, the development of the neuropeptide Y fibers in these areas is inhibitorily affected by that of arcuate neuropeptide Y neurons.
在大鼠下丘脑，含神经肽Y的神经元最早在妊娠第14.5天出现在弓状核和下丘脑背外侧区。直至出生，含神经肽Y的细胞体在弓状核、背内侧-外侧核和室旁核中的数量增加，但此后消失，不过仍有一些细胞留在弓状核中。在用L-谷氨酸单钠处理新生动物以破坏弓状核的实验中，在第16天，许多散在于大细胞室旁核和下丘脑背内侧-外侧核中的细胞出现了神经肽Y免疫反应性，而在第60天和第12天则未出现。这些出现在室旁核中的神经肽Y免疫反应性神经元也是加压素阳性的。相反，神经肽Y纤维在第16天数量显著减少，尤其是在室旁核、背内侧-外侧核和视前内侧区，但在第60天和第120天有相当程度的恢复。因此，在正常的个体发育过程中，这些区域中神经肽Y纤维的发育可能受到弓状核神经肽Y神经元发育的抑制性影响。
