Dash S, Brewer G J
Clin Chim Acta. 1978 Feb 1;83(1-2):182-4. doi: 10.1016/0009-8981(78)90223-1.
An increase in hydrogen ion dissociation was found on sickling due to sickle cell haemoglobin polymerization. Since a decrease in pH favours sickling, this might enhance the sickling process in a vicious cycle.
由于镰状细胞血红蛋白聚合,镰变时发现氢离子解离增加。由于pH值降低有利于镰变,这可能会在恶性循环中加剧镰变过程。