The University of Queensland Diamantina Institute, Level 4, R Wing, Princess Alexandra Hospital, Ipswich Road, Brisbane, QLD 4102, Australia.
Nat Rev Rheumatol. 2013 Jun;9(6):375-9. doi: 10.1038/nrrheum.2012.205. Epub 2012 Dec 11.
The proinflammatory cytokine IL-17 has an important role in pathogenesis of several inflammatory diseases. In immune-mediated joint diseases, IL-17 can induce secretion of other proinflammatory cytokines such as IL-1, IL-6 and TNF, as well as matrix metalloproteinase enzymes, leading to inflammation, cartilage breakdown, osteoclastogenesis and bone erosion. In animal models of inflammatory arthritis, mice deficient in IL-17 are less susceptible to development of disease. The list of IL-17-secreting cells is rapidly growing, and mast cells have been suggested to be a dominant source of IL-17 in inflammatory joint disease. However, many other innate sources of IL-17 have been described in both inflammatory and autoinflammatory conditions, raising questions as to the role of mast cells in orchestrating joint inflammation. This article will critically assess the contribution of mast cells and other cell types to IL-17 production in the inflammatory milieu associated with inflammatory arthritis, understanding of which could facilitate targeted therapeutic approaches.
促炎细胞因子白细胞介素 17（IL-17）在几种炎症性疾病的发病机制中具有重要作用。在免疫介导的关节疾病中，IL-17 可诱导其他促炎细胞因子（如白细胞介素 1、白细胞介素 6 和肿瘤坏死因子）以及基质金属蛋白酶的分泌，导致炎症、软骨破坏、破骨细胞生成和骨质侵蚀。在炎症性关节炎的动物模型中，缺乏白细胞介素 17 的小鼠对疾病的发展敏感性降低。IL-17 分泌细胞的清单正在迅速增加，肥大细胞被认为是炎症性关节病中白细胞介素 17 的主要来源。然而，在炎症和自身炎症条件下，许多其他先天来源的白细胞介素 17 已经被描述，这引发了关于肥大细胞在调节关节炎症中的作用的问题。本文将批判性地评估肥大细胞和其他细胞类型在与炎症性关节炎相关的炎症环境中产生白细胞介素 17 的贡献，这有助于针对这些细胞开发靶向治疗方法。
