Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
Antimicrob Agents Chemother. 2013 Feb;57(2):1073-6. doi: 10.1128/AAC.01886-12. Epub 2012 Dec 10.
The entire plasmid content of a multidrug-resistant, CTX-M-15-producing Klebsiella pneumoniae ST416 clone was investigated. Two FII(K) plasmids, pKDO1 (127 kb) and pKPN-CZ (207 kb), were identified and found to carry a formidable set of genes conferring resistance to toxic compounds, metals, and antimicrobial drugs and exhibiting novel features putatively associated with adaptation and fitness of the bacterium in the human host.
对一株产 CTX-M-15 的多药耐药肺炎克雷伯菌 ST416 克隆的整个质粒含量进行了研究。鉴定出两个 FII(K) 质粒，pKDO1（127kb）和 pKPN-CZ（207kb），它们携带了一系列令人畏惧的基因，赋予了对有毒化合物、金属和抗菌药物的抗性，并表现出与细菌在人体宿主中适应和生存能力相关的新特征。
