Hatai Hitoshi, Iba Mitsuru, Kojima Daisuke, Park Chun-Ho, Tsuchida Yasuhiko, Oyamada Toshifumi
Laboratory of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, Higashi 23-35-1, Towada, Aomori 034-8628, Japan.
J Vet Med Sci. 2013;75(5):639-41. doi: 10.1292/jvms.12-0446. Epub 2012 Dec 10.
A 13-year-old castrated male Labrador retriever dog presented with a mass caudal to the first molar of his left mandible. Although the tumor was excised, a recurrent tumor was detected one month later and resected. Both tumors displayed invasive growth and were composed of neoplastic proliferation arranged in irregular lobules, nests and cords continuous with mucosal epithelium. The most prominent feature of the tumors was the presence of many proliferating spindle cells admixed with palisading basal-like cells, acanthocytes and stellate cells. In immunohistochemical examinations, the spindle cells were found to be positive for vimentin; cytokeratin AE1/AE3, 5/6, 14 and 19; and p63. The other neoplastic cells were positive for all of these markers shown above except vimentin. Based on these findings, the tumors were diagnosed as spindle cell ameloblastic carcinoma.
一只13岁去势雄性拉布拉多猎犬左侧下颌第一磨牙后方出现肿物。尽管肿瘤已被切除，但1个月后发现复发肿瘤并再次切除。两个肿瘤均呈浸润性生长，由与黏膜上皮相连的不规则小叶、巢状和条索状肿瘤性增殖构成。肿瘤最显著的特征是存在许多增生的梭形细胞，混有栅栏状基底样细胞、棘状细胞和星状细胞。免疫组化检查发现，梭形细胞波形蛋白、细胞角蛋白AE1/AE3、5/6、14和19以及p63呈阳性。除波形蛋白外，其他肿瘤细胞对上述所有标记物均呈阳性。根据这些发现，肿瘤被诊断为梭形细胞成釉细胞癌。
