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韩国一例伴有蛋白丢失性肠病的本土肠毛细线虫病病例。

An indigenous case of intestinal capillariasis with protein-losing enteropathy in Korea.

作者信息

Jung Woon Tae, Kim Hyun Jin, Min Hyun Ju, Ha Chang Yoon, Kim Hong Jun, Ko Gyung Hyuck, Na Byoung-Kuk, Sohn Woon-Mok

机构信息

Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju 660-751, Korea.

出版信息

Korean J Parasitol. 2012 Dec;50(4):333-7. doi: 10.3347/kjp.2012.50.4.333. Epub 2012 Nov 26.

DOI:10.3347/kjp.2012.50.4.333
PMID:23230331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3514425/
Abstract

We encountered an indigenous case of intestinal capillariasis with protein-losing enteropathy in the Republic of Korea. A 37-year-old man, residing in Sacheon-si, Gyeongsangnam-do, admitted to the Gyeongsang National University Hospital (GNUH) due to long-lasting diarrhea, abdominal pain, anasarca, and weight loss. He recalled that he frequently ate raw fish, especially the common blackish goby (Acanthogobius flavimanus) and has never been abroad. Under the suspicion of protein-losing enteropathy, he received various kinds of medical examinations, and was diagnosed as intestinal capillariasis based on characteristic sectional findings of nematode worms in the biopsied small intestine. Adults, juvenile worms, and eggs were also detected in the diarrheic stools collected before and after medication. The clinical symptoms became much better after treatment with albendazole 400 mg daily for 3 days, and all findings were in normal range in laboratory examinations performed after 1 month. The present study is the 6th Korean case of intestinal capillariasis and the 3rd indigenous one in the Republic of Korea.

摘要

我们在大韩民国遇到了一例伴有蛋白丢失性肠病的本土肠毛细线虫病病例。一名37岁男子居住在庆尚南道泗川市,因长期腹泻、腹痛、全身性水肿和体重减轻入住庆尚国立大学医院(GNUH)。他回忆说自己经常吃生鱼,尤其是中华乌塘鳢,且从未出过国。在怀疑患有蛋白丢失性肠病的情况下,他接受了各种医学检查,并根据活检小肠中特征性的线虫断面发现被诊断为肠毛细线虫病。在用药前后收集的腹泻粪便中也检测到了成虫、幼虫和虫卵。每天服用400毫克阿苯达唑,持续3天进行治疗后,临床症状明显好转,1个月后进行的实验室检查中所有结果均在正常范围内。本研究是韩国第6例肠毛细线虫病病例,也是大韩民国第3例本土病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6985/3514425/94b66b50afa9/kjp-50-333-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6985/3514425/cf6ddf1237fb/kjp-50-333-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6985/3514425/94b66b50afa9/kjp-50-333-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6985/3514425/cf6ddf1237fb/kjp-50-333-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6985/3514425/94b66b50afa9/kjp-50-333-g002.jpg

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本文引用的文献

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Indian J Med Microbiol. 2012 Apr-Jun;30(2):236-9. doi: 10.4103/0255-0857.96708.
2
Capillaria philippinensis in Upper Egypt: has it become endemic?埃及上埃及的菲律宾毛细线虫:它是否已成为地方性疾病?
Am J Trop Med Hyg. 2012 Jan;86(1):126-33. doi: 10.4269/ajtmh.2012.11-0321.
3
Three cases of intestinal capillariasis in Lao People's Democratic Republic.老挝人民民主共和国的三例肠道毛细线虫病病例。
近25年归国旅行者中食源性线虫病概述——意想不到的疾病有时远离源头。
Korean J Parasitol. 2018 Jun;56(3):215-227. doi: 10.3347/kjp.2018.56.3.215. Epub 2018 Jun 30.
4
Intestinal capillariasis in the 21st century: clinical presentations and role of endoscopy and imaging.21世纪的肠道毛细线虫病:临床表现及内镜检查与影像学的作用
BMC Gastroenterol. 2014 Dec 10;14:207. doi: 10.1186/s12876-014-0207-9.
5
Intestinal capillariasis diagnosed by endoscopic biopsy.经内镜活检确诊的肠道毛细线虫病。
Clin Endosc. 2013 Nov;46(6):675-8. doi: 10.5946/ce.2013.46.6.675. Epub 2013 Nov 19.
Am J Trop Med Hyg. 2008 Nov;79(5):735-8.
4
Human intestinal capillariasis in Thailand.泰国的人体肠道毛细线虫病。
World J Gastroenterol. 2008 Jan 28;14(4):506-10. doi: 10.3748/wjg.14.506.
5
Human intestinal capillariasis (Capillaria philippinensis) in Taiwan.台湾的人体肠道毛细线虫病(菲律宾毛细线虫)
Am J Trop Med Hyg. 2006 May;74(5):810-3.
6
Compostela Valley: a new endemic focus for Capillariasis philippinensis.康波斯特拉山谷:菲律宾毛细线虫病的一个新的地方性疫源地。
Southeast Asian J Trop Med Public Health. 2000 Sep;31(3):478-81.
7
A case of intestinal capillariasis in the Republic of Korea.大韩民国的一例肠道毛细线虫病病例。
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8
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Clin Infect Dis. 1993 Nov;17(5):909-12. doi: 10.1093/clinids/17.5.909.
9
Two cases of intestinal capillariasis in Korea.韩国的两例肠道毛细线虫病病例。
Korean J Parasitol. 1994 Mar;32(1):43-8. doi: 10.3347/kjp.1994.32.1.43.
10
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Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):204. doi: 10.1016/0035-9203(94)90296-8.