Coude M, Chadefaux B, Rabier D, Kamoun P
Laboratoire de Biochimie Médicale B, Hôpital Necker Enfants Malades, Paris, France.
Clin Chim Acta. 1990 Mar 15;187(3):329-32. doi: 10.1016/0009-8981(90)90118-c.
Organic acids were studied in amniotic fluids taken by early amniocentesis between 6 to 12 weeks in control pregnancies. The prenatal diagnosis of methylmalonic acidemia and propionic acidemia could be made by the measurement of methylmalonic and methylcitric acid respectively in the amniotic fluid taken simultaneously with chorionic villi at the 11th week of gestation.
对处于对照孕期的孕妇，在妊娠6至12周时通过早期羊膜腔穿刺采集的羊水进行有机酸研究。在妊娠第11周采集绒毛膜绒毛的同时采集羊水，分别测定其中的甲基丙二酸和甲基柠檬酸，可对甲基丙二酸血症和丙酸血症进行产前诊断。
