急性病毒性肝炎中获得性红细胞葡萄糖-6-磷酸脱氢酶酶病
Acquired enzymopathy of erythrocyte glucose-6-phosphate dehydrogenase in acute viral hepatitis.
作者信息
Kwiatkowska J, Kwiatkowska D, Andrzejak R, Zatoński W
出版信息
Clin Chim Acta. 1978 Feb 1;83(1-2):75-9. doi: 10.1016/0009-8981(78)90209-7.
Erythrocyte glucose-6-phosphate dehydrogenase from patients with acute viral hepatitis has been purified and characterized. The enzyme showed decreased activity (relative to protein), reduced affinity for glucose 6-phosphate and was inactivated at 45 degrees C or at low pH values. The activity and properties of normal erythrocyte enzyme, incubated in vitro with blood plasma of patients, showed a similar pattern of modifications. Incubation with bilirubin affected the enzyme stability, but not its activity or affinity for substrate.
急性病毒性肝炎患者的红细胞葡萄糖-6-磷酸脱氢酶已被纯化并进行了特性分析。该酶活性（相对于蛋白质）降低，对6-磷酸葡萄糖的亲和力降低，并且在45℃或低pH值下失活。将正常红细胞酶与患者血浆在体外孵育，其活性和特性呈现出类似的修饰模式。与胆红素孵育会影响酶的稳定性，但不影响其活性或对底物的亲和力。
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