National Institute of Neurological Disorders and Stroke, Behavioral Neurology Unit, Bethesda, MD, USA.
NeuroRehabilitation. 2012;31(4):367-72. doi: 10.3233/NRE-2012-00805.
Many service members and veterans report chronic unexplained symptoms such as pain, fatigue and memory complaints, which have most recently been characterized as post-deployment syndrome (PDS). Chronic widespread pain is a component of this syndrome, producing significant disability and considerable health care costs. The similarity between the nature of these complaints and other medically unexplained illnesses such as fibromyalgia, irritable bowel syndrome, and chronic fatigue syndrome suggest that they may share a common mechanism. Here, we provide support for PDS as a consequence of pain and sensory amplification secondary to neuroplastic changes within the central nervous system, a phenomenon often termed central sensitization. We also discuss how factors such as stress and genetics may promote chronic widespread pain in veterans and service members who develop PDS.
许多军人和退伍军人报告有慢性不明原因的症状，如疼痛、疲劳和记忆问题，最近被描述为部署后综合征（PDS）。慢性广泛性疼痛是这种综合征的一个组成部分，会导致严重的残疾和相当大的医疗保健费用。这些投诉的性质与其他医学上无法解释的疾病（如纤维肌痛、肠易激综合征和慢性疲劳综合征）非常相似，这表明它们可能有共同的机制。在这里，我们支持 PDS 是由于中枢神经系统内神经可塑性变化引起的疼痛和感觉放大的结果，这种现象通常被称为中枢敏化。我们还讨论了压力和遗传等因素如何促进患有 PDS 的退伍军人和军人中慢性广泛性疼痛的发生。
