[复发性流产女性循环抗精子抗体的临床研究]

[Clinical study on circulating antisperm antibodies in women with recurrent abortion].

作者信息

Zhang X C

出版信息

Zhonghua Fu Chan Ke Za Zhi. 1990 Jan;25(1):21-3, 61-2.

Abstract

Couples with a history of recurrent spontaneous abortions (RSA) were analyzed for circulating antisperm antibodies (Ab) with an enzyme-linked immunosorbent assay (ELISA), a Franklin-Dukes (F-D) and a sperm immobilization test(SIT). The three tests were positive in 31.5%, 25.9% and 18.5% for wives and 24.1%, 11.1% and 7.4% for husbands in RSA couples. There was a statistical significance (P less than 0.01) as compared with the control group. The ELISA method was found to be most sensitive, and the positive rate of antisperm antibodies in wives was higher than that in husbands. The Ab titer of RSA group varied within 1:8 approximately 1:512, with 60% above 1:32. The pregnant weeks (P greater than 0.05) did not seem to affect the antisperm Ab titer, nor did the aborting frequency. Our study suggests that antisperm Ab is one of the important causes of RSA in women.

摘要

采用酶联免疫吸附测定（ELISA）、富兰克林 - 杜克斯（F - D）法和精子制动试验（SIT），对有复发性自然流产（RSA）病史的夫妇进行循环抗精子抗体（Ab）分析。在RSA夫妇中，这三项检测中妻子的阳性率分别为31.5%、25.9%和18.5%，丈夫的阳性率分别为24.1%、11.1%和7.4%。与对照组相比，差异具有统计学意义（P小于0.01）。发现ELISA法最敏感，妻子中抗精子抗体的阳性率高于丈夫。RSA组的抗体滴度在1:8至约1:512之间变化，60%高于1:32。妊娠周数（P大于0.05）似乎不影响抗精子抗体滴度，流产频率也不影响。我们的研究表明，抗精子抗体是女性RSA的重要原因之一。