Department of Medicine, Division of Hematology, Johns Hopkins University, Baltimore, MD 21205, USA.
Hematology Am Soc Hematol Educ Program. 2012;2012:208-14. doi: 10.1182/asheducation-2012.1.208.
Pregnancy poses a unique challenge to patients with sickle cell disease and β-thalassemia, who often have exacerbations of hemolysis or anemia during the gestational period, experience higher rates of obstetric and fetal complications, and may have distinct underlying comorbidities related to vasculopathy and iron overload that can endanger maternal health. Optimal management of pregnant women with hemoglobinopathies requires both an understanding of the physiologic demands of pregnancy and the pathophysiology of disease-specific complications of inherited blood disorders. A multidisciplinary team of expert hematologists and high-risk obstetricians is therefore essential to ensuring appropriate antenatal maternal screening, adequate fetal surveillance, and early recognition of complications. Fortunately, with integrated and targeted care, most women with sickle cell disease and β-thalassemia can achieve successful pregnancy outcomes.
妊娠给镰状细胞病和β-地中海贫血患者带来了独特的挑战，这些患者在妊娠期往往会出现溶血或贫血加重，并且更易发生产科和胎儿并发症，还可能存在与血管病变和铁过载相关的独特合并症，从而危及母体健康。患有血红蛋白病的孕妇的最佳管理需要了解妊娠的生理需求和遗传性血液疾病特定并发症的病理生理学。因此，多学科专家血液科医生和高危产科医生团队对于确保适当的产前母体筛查、充分的胎儿监测以及早期识别并发症至关重要。幸运的是，通过综合和有针对性的护理，大多数镰状细胞病和β-地中海贫血患者都可以实现成功的妊娠结局。
