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抗胸腺细胞球蛋白在降低强度预处理的异基因造血干细胞移植中是否有一席之地?

Does antithymocyte globulin have a place in reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation?

机构信息

Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.

出版信息

Hematology Am Soc Hematol Educ Program. 2012;2012:246-50. doi: 10.1182/asheducation-2012.1.246.

Abstract

A 63-year-old male patient without siblings is treated for acute myeloid leukemia with poor prognostic cytogenetics. Despite achieving a first complete remission, he relapsed within the first year of diagnosis. He then achieved a second complete remission. A search for an HLA-identical unrelated donor identified a 10/10 possible match. The patient has several comorbidities (hematopoietic stem cell comorbidity index = 3) and it is recommended that he undergo a reduced-intensity conditioning regimen for allogeneic peripheral blood stem cell transplantation. The patient is well-read on allogeneic stem cell transplantation and asks you the merits of antithymocyte globulin that you propose to include in the conditioning regimen.

摘要

一位 63 岁的男性患者,无兄弟姐妹,患有预后不良的细胞遗传学急性髓系白血病。尽管他首次达到完全缓解,但在诊断后的第一年就复发了。然后他又达到了第二次完全缓解。寻找 HLA 完全相同的无关供体发现了一个 10/10 可能匹配的供体。患者有多种合并症(造血干细胞合并症指数 = 3),建议他接受异体外周血造血干细胞移植的低强度预处理方案。该患者对异基因干细胞移植有深入的了解,他询问了您提出的在预处理方案中加入抗胸腺细胞球蛋白的优点。

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