Department of Hematology/Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA.
Hematology Am Soc Hematol Educ Program. 2012;2012:246-50. doi: 10.1182/asheducation-2012.1.246.
A 63-year-old male patient without siblings is treated for acute myeloid leukemia with poor prognostic cytogenetics. Despite achieving a first complete remission, he relapsed within the first year of diagnosis. He then achieved a second complete remission. A search for an HLA-identical unrelated donor identified a 10/10 possible match. The patient has several comorbidities (hematopoietic stem cell comorbidity index = 3) and it is recommended that he undergo a reduced-intensity conditioning regimen for allogeneic peripheral blood stem cell transplantation. The patient is well-read on allogeneic stem cell transplantation and asks you the merits of antithymocyte globulin that you propose to include in the conditioning regimen.
一位 63 岁的男性患者,无兄弟姐妹,患有预后不良的细胞遗传学急性髓系白血病。尽管他首次达到完全缓解,但在诊断后的第一年就复发了。然后他又达到了第二次完全缓解。寻找 HLA 完全相同的无关供体发现了一个 10/10 可能匹配的供体。患者有多种合并症(造血干细胞合并症指数 = 3),建议他接受异体外周血造血干细胞移植的低强度预处理方案。该患者对异基因干细胞移植有深入的了解,他询问了您提出的在预处理方案中加入抗胸腺细胞球蛋白的优点。