含膦的环十肽短杆菌素 S 衍生物：不对称催化的新型配体。
Cyclic decapeptide gramicidin S derivatives containing phosphines: novel ligands for asymmetric catalysis.
机构信息
EaStCHEM, School of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST, UK.
出版信息
Dalton Trans. 2013 Feb 14;42(6):1973-8. doi: 10.1039/c2dt31782f.
PMID:23235486
Abstract
The cyclic peptide gramicidin S was used as a rigid template to provide novel peptide-based bisphosphine ligands for transition metal catalysis. Two bisphosphine-coordinated Rh(I) complexes allowed asymmetric hydrogenation with 10-52% ee and the corresponding Pd(II) analogues catalysed asymmetric allylic alkylation with 13-15% ee.
摘要
环状多肽短杆菌肽 S 被用作刚性模板，为过渡金属催化提供了新型基于肽的双膦配体。两个双膦配位的 Rh(I) 配合物允许进行不对称氢化，ee 值为 10-52%，相应的 Pd(II) 类似物则催化不对称烯丙基烷基化，ee 值为 13-15%。
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