Ghoshal A K, Rushmore T H, Buc-Calderon P, Roberfroid M, Farber E
Department of Pathology, University of Toronto, Ontario, Canada.
Free Radic Biol Med. 1990;8(1):3-7. doi: 10.1016/0891-5849(90)90137-8.
This study was designed to explore the possible preventive effects of a novel radicophile, N-p-methoxyphenylacetyl-dehydroalanine (AD5) and three other antioxidants, N,N'-diphenyl-p-phenylenediamine (DPPD), butylated hydroxyanisole (BHA) and a water-soluble analogue of vitamin E, trolox C, on the acute effects of the liver of feeding a choline-deficient (CD) diet. It has been suggested that some of the acute effects of a CD diet are related to free radicals, the generation or metabolism of which is disturbed in this acute dietary model. AD5 was found to be very effective in preventing nuclear lipid peroxidation, DNA damage and cell death induced by a CD diet but to have little effect on triglyceride accumulation ("fatty liver"). DPPD, BHA, and trolox C were ineffective. These results add strength to the hypothesis that oxygen free radicals might be an important component in the early events during carcinogenesis induced by feeding a CD diet.
本研究旨在探究一种新型亲核试剂N-对甲氧基苯基乙酰基脱氢丙氨酸（AD5）以及其他三种抗氧化剂N,N'-二苯基对苯二胺（DPPD）、丁基羟基茴香醚（BHA）和维生素E的水溶性类似物生育酚C对喂食胆碱缺乏（CD）饮食的肝脏急性影响的可能预防作用。有人提出，CD饮食的一些急性影响与自由基有关，在这种急性饮食模型中，自由基的产生或代谢受到干扰。结果发现，AD5在预防CD饮食诱导的核脂质过氧化、DNA损伤和细胞死亡方面非常有效，但对甘油三酯积累（“脂肪肝”）几乎没有影响。DPPD、BHA和生育酚C无效。这些结果进一步支持了以下假设：氧自由基可能是喂食CD饮食诱导致癌早期事件中的一个重要组成部分。
