Gastroenterohepatology Research Center, Shiraz Transplant Research Center, Nemazee Teaching Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71937-11351, Iran.
World J Gastroenterol. 2012 Dec 7;18(45):6541-5. doi: 10.3748/wjg.v18.i45.6541.
Solitary rectal ulcer syndrome (SRUS) is a benign and chronic disorder well known in young adults and less in children. It is often related to prolonged excessive straining or abnormal defecation and clinically presents as rectal bleeding, copious mucus discharge, feeling of incomplete defecation, and rarely rectal prolapse. SRUS is diagnosed based on clinical symptoms and endoscopic and histological findings. The current treatments are suboptimal, and despite correct diagnosis, outcomes can be unsatisfactory. Some treatment protocols for SRUS include conservative management such as family reassurance, regulation of toilet habits, avoidance of straining, encouragement of a high-fiber diet, topical treatments with salicylate, sulfasalazine, steroids and sucralfate, and surgery. In children, SRUS is relatively uncommon but troublesome and easily misdiagnosed with other common diseases, however, it is being reported more than in the past. This condition in children is benign; however, morbidity is an important problem as reflected by persistence of symptoms, especially rectal bleeding. In this review, we discuss current diagnosis and treatment for SRUS.
孤立性直肠溃疡综合征(SRUS)是一种良性且慢性的疾病,在年轻人中较为常见,在儿童中则较少见。它通常与长时间过度用力或排便异常有关,临床上表现为直肠出血、大量黏液排出、排便不尽感,很少出现直肠脱垂。SRUS 基于临床症状和内镜及组织学发现进行诊断。目前的治疗方法效果不佳,尽管诊断正确,结果仍可能不尽如人意。一些 SRUS 的治疗方案包括保守治疗,如家庭安慰、调整排便习惯、避免用力、鼓励高纤维饮食、局部使用柳氮磺胺吡啶、皮质类固醇和硫酸蔗糖,以及手术治疗。在儿童中,SRUS 相对少见,但很麻烦,容易与其他常见疾病误诊,然而,现在比过去报告的更多。这种儿童疾病是良性的;然而,发病率是一个重要问题,表现为症状持续存在,尤其是直肠出血。在这篇综述中,我们讨论了 SRUS 的当前诊断和治疗方法。