Biswas Archita, Gomes Aparna, Sengupta Jayeeta, Datta Poulami, Singha Santiswarup, Dasgupta Anjan Kr, Gomes Antony
Drug Development/Diagnostics and Biotechnology Division, Indian Institute of Chemical Biology, 4 Raja SC Mullick Road, Kolkata - 700 032, Kolkata, India.
J Venom Res. 2012;3:15-21. Epub 2012 Oct 23.
Nano-medical approaches to develop drugs have attracted much attention in different arenas to design nanoparticle conjugates for better efficacy of the potential bio-molecules. A group of promising candidates of this category would be venom-toxins of animal origin of potential medicinal value. Traditional systems of medicine as well as folklores mention the use of venom-toxins for the treatment of various diseases. Research has led to scientific validation of medicinal applications of venoms-toxins and many active constituents derived from venoms-toxins are already in clinical use or under clinical trial. Nanomedicine is an emerging field of medicine where nanotechnology is used to develop molecules of nano-scale dimension, so that these molecules can be taken up by the cells more easily and have better efficacy, as compared to large molecules that may tend to get eliminated. This review will focus on some of the potential venoms and toxins along with nanoparticle conjugated venom-toxins of snakes, amphibians, scorpions and bees, etc., for possible therapeutic clues against emerging diseases.
纳米医学方法开发药物在不同领域引起了广泛关注，旨在设计纳米颗粒缀合物以提高潜在生物分子的疗效。这类有前景的候选物之一是具有潜在药用价值的动物源毒液毒素。传统医学体系以及民间传说都提到了使用毒液毒素治疗各种疾病。研究已对毒液毒素的药用应用进行了科学验证，许多源自毒液毒素的活性成分已在临床使用或正在进行临床试验。纳米医学是一个新兴的医学领域，利用纳米技术开发纳米级尺寸的分子，与可能容易被清除的大分子相比，这些分子能够更轻松地被细胞摄取并具有更好的疗效。本综述将聚焦于一些潜在的毒液和毒素，以及与蛇、两栖动物、蝎子和蜜蜂等的纳米颗粒缀合毒液毒素，以寻找针对新兴疾病的可能治疗线索。
