Gao Jian, Yang Geng-liang, Yang Hong-jun, Xu Hai-yu, Li Shao-jing
College of Pharmaceutical Science, Hebei University, Baoding 071002, China.
Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2519-23.
Metabolomics is an emerging discipline subsequent to genomics, transcriptomics and proteomics, aiming for systematically studying the regularity of changes in metabolite to revealing organism's nature of movement and metabolism. It is especially important in modern pharmacological studies. Metabolic fingerprinting analysis is a method for metabolic analysis on high throughput of all metabolites, studying changes in drugs, organisms and endogenic metabolites caused by drugs and finding out related biomarkers to reflect dynamic changes inside organisms more directly and explain the mechanism of drugs and their effects on diseases. This essay summarizes some new metabolic fingerprint analytical methods and data processing methods used for metabolic fingerprint, elaborates their advantages and disadvantages and looks ahead to their combination with studies on traditional Chinese medicines, providing room for the development of new methods and new approaches for studies on complexity theory system of traditional Chinese medicines.
代谢组学是继基因组学、转录组学和蛋白质组学之后兴起的一门学科，旨在系统研究代谢物变化规律以揭示生物体的运动和代谢本质。它在现代药理学研究中尤为重要。代谢指纹分析是一种对所有代谢物进行高通量代谢分析的方法，研究药物、生物体及内源性代谢物因药物引起的变化，找出相关生物标志物，更直接地反映生物体内的动态变化，解释药物作用机制及其对疾病的影响。本文综述了一些用于代谢指纹的新型代谢指纹分析方法和数据处理方法，阐述了它们的优缺点，并展望了其与中药研究的结合，为中药复杂理论体系研究新方法和新途径的发展提供空间。
