Faculty of Health Sciences, University of Queensland, Royal Brisbane and Women's Hospital, Herston, Brisbane, QLD 4027, Australia.
Expert Rev Neurother. 2012 Dec;12(12):1419-27. doi: 10.1586/ern.12.129.
Contemporary drug therapy fails to control epileptic seizures in some 30% of patients, resulting in the need to employ other measures when they appear practicable. A good deal of potentially relevant statistical detail is available regarding the outcomes of the available antiepileptic therapies, but its interpretation is sometimes difficult because of uncertainty about the types of epilepsy to which it applies, and because of deficiencies in knowledge of the natural histories of the various epileptic syndromes, if untreated. The actual shortcomings in the contemporary treatment of epilepsy appear to arise not only from the limited curative capacities of the available therapies, but from a number of deficiencies in knowledge concerning the significant aspects of what should determine treatment policy and the optimal employment of antiepileptic drugs.
当代药物疗法未能控制约 30%的癫痫发作患者，因此当这些患者出现可行的治疗方法时，需要采用其他措施。对于现有抗癫痫治疗的结果，有大量潜在相关的统计细节，但由于对适用癫痫类型的不确定性，以及对各种癫痫综合征未经治疗的自然史的知识不足，其解释有时很困难。当代癫痫治疗的实际缺陷不仅源于现有疗法的治疗能力有限，而且还源于在决定治疗策略和最佳使用抗癫痫药物的重要方面的知识存在若干缺陷。
