Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, 100 High Street, Buffalo, NY 14203, USA.
Expert Rev Neurother. 2012 Dec;12(12):1467-80. doi: 10.1586/ern.12.128.
Over the decades, various studies have established an association between accumulation of iron and both aging and neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Excess levels of iron can lead to increased oxidative stress through Fenton chemistry, and depletion of iron can similarly have deleterious effects. In addition, metal ions are known to be involved in both Alzheimer's disease and Parkinson's disease protein aggregation. Metal ion chelators have been extensively investigated in preclinical models, and may prove to be appropriate for modulating brain iron levels in age-related neurodegenerative disorders. Investigating age-related iron deposition is vital, and can possibly aid in determining at-risk groups and diagnosing neurodegenerative diseases at an early stage. Novel imaging methods have enabled researchers to examine iron deposition in vivo, and offer a noninvasive method of monitoring the progression of accumulation, and possible therapeutic effects of chelating compounds.
几十年来，各种研究已经证实，铁的积累与衰老和神经退行性疾病（如阿尔茨海默病和帕金森病）之间存在关联。过量的铁会通过芬顿化学导致氧化应激增加，而铁的消耗也会产生类似的有害影响。此外，金属离子已知与阿尔茨海默病和帕金森病的蛋白质聚集有关。金属离子螯合剂在临床前模型中已经得到了广泛的研究，它们可能适合调节与年龄相关的神经退行性疾病中的大脑铁水平。研究与年龄相关的铁沉积至关重要，并且可能有助于确定高危人群，并在早期诊断神经退行性疾病。新型成像方法使研究人员能够在体内检查铁沉积，并提供一种非侵入性的方法来监测积累的进展和螯合化合物的可能治疗效果。
