Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN, USA.
Am J Transplant. 2013 Jan;13 Suppl 1:47-72. doi: 10.1111/ajt.12020.
Numbers of pancreas transplants have been decreasing over the past decade, but outcomes continue to improve for all types: simultaneous pancreas-kidney transplant, pancreas after kidney transplant (PAK), and pancreas transplant alone (PTA). The most notable decrease occurred for PAK transplants, possibly due in part to decreases in numbers of living donor kidney transplants. The number of new candidates on the pancreas transplant waiting list has decreased steadily since 2000; only 1005 active candidates were added in 2011. Transplant rates for all pancreas transplant types reached a low in 2011 of 34.9 transplants per 100 wait-list years. Deceased donation rates have also been decreasing since 2005, but use of donation after circulatory death has been gradually increasing. The discard rate in 2011 was 27.7%, and higher for pancreata recovered from older donors. Improved outcomes during the early posttransplant period largely reflect improved donor and recipient selection and improved technical strategies. Inconsistent definitions of graft failure across reporting centers creates an ongoing challenge in the interpretation of outcome data for pancreas transplants. Rates of posttransplant re-hospitalization are high, most occurring in the first 6 months. Rejection rates are highest for PTA recipients, who also experience higher incidence of posttransplant lymphoproliferative disorder.
在过去的十年中，胰腺移植的数量一直在减少，但所有类型的移植（胰肾联合移植、肾移植后胰腺移植和单纯胰腺移植）的结果都在持续改善。最显著的减少发生在 PAK 移植中，部分原因可能是活体供肾移植数量的减少。自 2000 年以来，新的胰腺移植候选者数量一直在稳步下降；2011 年仅增加了 1005 名活跃候选者。所有胰腺移植类型的移植率在 2011 年达到了每 100 个等待名单年 34.9 次移植的低点。自 2005 年以来，脑死亡后捐赠的数量也一直在减少，但使用循环死亡后的捐赠一直在逐渐增加。2011 年的丢弃率为 27.7%，从较年长的供体中回收的胰腺丢弃率更高。在移植后早期的结果改善在很大程度上反映了供体和受体选择的改善和技术策略的改进。由于各报告中心对移植物失功的定义不一致，这对胰腺移植结果数据的解释构成了持续挑战。移植后再住院的比率很高，大多数发生在最初的 6 个月内。PTA 受者的排斥反应率最高，他们也经历更高的移植后淋巴增殖性疾病发生率。
