Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN, USA.
Am J Transplant. 2013 Jan;13 Suppl 1:103-18. doi: 10.1111/ajt.12022.
Since 2006, the number of new intestinal transplant candidates listed each year has declined, likely reflecting increased medical and surgical treatment for intestinal failure. Historically, intestinal transplant occurred primarily in the pediatric population; in 2011, 41% of prevalent candidates on the waiting list were aged 18 years or older. The most common etiology of intestinal failure remains short-gut syndrome, which encompasses several diagnoses. The proportion of candidates with high medical urgency status decreased and time on the waiting list increased in 2011. The overall rate of transplant decreased from a peak of 92.7 transplants per 100 wait-list years in 2005 to 49.2 in 2011. The number of intestines recovered and transplanted per donor has decreased since 2007, possibly due to fewer listed patients. Almost 50% of deceased donor intestines were transplanted with another organ in 2011. Historically, the most common organ transplanted with the intestine was the liver, but in 2011 it was the pancreas. Graft survival has continued to improve over the past decade, and the number of recipients alive with a functioning intestinal graft has steadily increased since 1998. Hospitalization is common, occurring in 84.8% of recipients by 6 months posttransplant and in almost all by 4 years.
自 2006 年以来,每年列出的新肠移植候选人数有所下降,这可能反映出对肠衰竭的医疗和手术治疗有所增加。从历史上看,肠移植主要发生在儿科人群中;2011 年,等待名单上的 41%的现有候选者年龄在 18 岁或以上。肠衰竭的最常见病因仍然是短肠综合征,它包含几种诊断。2011 年,具有高医疗紧迫性状态的候选者比例下降,等待名单上的时间增加。2011 年,移植的总体比率从 2005 年每 100 个等待名单年 92.7 例移植的峰值下降到 49.2 例。自 2007 年以来,每供体回收和移植的肠数量有所减少,这可能是由于列出的患者较少。2011 年,近 50%的已故供体肠与另一个器官一起移植。从历史上看,与肠一起移植的最常见器官是肝脏,但 2011 年是胰腺。在过去十年中,移植物存活率继续提高,自 1998 年以来,有功能的肠移植受者数量稳步增加。住院治疗很常见,84.8%的受者在移植后 6 个月内住院,几乎所有受者在 4 年内住院。