Departamento de Psicobiologia, Universidade Federal de São Paulo, Brazil.
J Ethnopharmacol. 2013 Jan 30;145(2):647-52. doi: 10.1016/j.jep.2012.12.004. Epub 2012 Dec 10.
HETEROPTERYS TOMENTOSA: A. Juss (Malpighiaceae), commonly mistaken as Heteropterys aphrodisiaca, is chronically used by the Brazilian population to improve general health due to its claimed protective effects against a wide range of medical conditions.
This study in rodents aimed to verify the adaptogenic potential of the hydroalcoholic extracts of the roots (the most commonly used portion), branches and leaves of the plant.
The phytochemical constitution of the extracts was analyzed through thin-layer chromatography and high-performance liquid chromatography. Restriction- and cold-induced stress in rats treated for 14 days with 100 or 300 mg/kg of the extracts were used to evaluate parameters such as ulceration, adrenals, thymus and spleen weights, as well as ACTH and corticosterone plasmatic levels. The stress response also was evaluated in mice by self-analgesia induced by restraint stress, after 7 days of treatment at doses of 100 and 300 mg/kg. The learning and memory of aged rats treated with extracts of root or branches at the dose of 50 mg/kg for 80 days were evaluated in the elevated T-maze test.
The chemical constituents of the three parts of the plant were relatively similar in the presence of saponins, hydrolysable tannins, flavonoids, polyphenols and triterpenes. None of the three extracts were capable of protecting the stomach from ulcerations in rats submitted to cold restraint stress or protecting from alterations in adrenal or spleen weight (p>0.05). Furthermore, the extracts did not inhibit increases in plasma levels of corticosterone and adrenocorticotropic hormone. Moreover, the extracts did not inhibit self-analgesia induced by restraint stress in mice and did not improve the performance of aged rats in the T-maze test (p>0.05).
The tests employed in this study did not show evidence of adaptogenic activity in the three extracts of Heteropterys tomentosa.
Heteropterys tomentosa：A. Juss（卫矛科），常被误认为 Heteropterys aphrodisiaca，由于其据称对多种医疗状况具有保护作用，巴西民众长期将其用于改善整体健康。
本研究旨在验证植物的根（最常用部分）、枝和叶的水醇提取物的适应原潜力。
通过薄层层析和高效液相色谱分析提取物的植物化学成分。用限制和冷应激在 14 天内用 100 或 300mg/kg 的提取物治疗的大鼠中评估溃疡、肾上腺、胸腺和脾脏重量以及 ACTH 和皮质酮血浆水平等参数。在 7 天的 100 和 300mg/kg 剂量治疗后，通过束缚应激诱导的自我镇痛，在小鼠中评估应激反应。用 50mg/kg 剂量的根或枝提取物治疗 80 天的老年大鼠，在高架 T 迷宫测试中评估学习和记忆能力。
在植物的三个部分中，皂苷、可水解单宁、类黄酮、多酚和三萜类化合物的化学成分相对相似。三种提取物均不能保护大鼠免受冷束缚应激引起的胃溃疡，也不能保护肾上腺或脾脏重量不受影响（p>0.05）。此外，提取物不能抑制皮质酮和促肾上腺皮质激素血浆水平的升高。此外，提取物不能抑制束缚应激引起的自我镇痛，也不能改善老年大鼠在 T 迷宫测试中的表现（p>0.05）。
本研究中使用的测试未显示 Heteropterys tomentosa 的三种提取物具有适应原活性的证据。
