蜂王浆对慢性应激大鼠肝脏的适应原潜力。
Adaptogenic potential of royal jelly in liver of rats exposed to chronic stress.
作者信息
Caixeta Douglas Carvalho, Teixeira Renata Roland, Peixoto Leonardo Gomes, Machado Helen Lara, Baptista Nathalia Belele, de Souza Adriele Vieira, Vilela Danielle Diniz, Franci Celso Rodrigues, Salmen Espindola Foued
机构信息
Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Department of Physiology, University of São Paulo, Ribeirão Preto, Minas Gerais, Brazil.
出版信息
PLoS One. 2018 Jan 29;13(1):e0191889. doi: 10.1371/journal.pone.0191889. eCollection 2018.
Restraint and cold stress increase both corticosterone and glycemia, which lead to oxidative damages in hepatic tissue. This study assessed the effect of royal jelly (RJ) supplementation on the corticosterone level, glycemia, plasma enzymes and hepatic antioxidant system in restraint and cold stressed rats. Wistar rats were allocated into no-stress, stress, no-stress supplemented with RJ and stress supplemented with RJ groups. Initially, RJ (200mg/Kg) was administered for fourteen days and stressed groups were submitted to chronic stress from the seventh day. The results showed that RJ supplementation decreases corticosterone levels and improves glycemia control after stress induction. RJ supplementation also decreased the body weight, AST, ALP and GGT. Moreover, RJ improved total antioxidant capacity, SOD activity and reduced GSH, GR and lipoperoxidation in the liver. Thus, RJ supplementation reestablished the corticosterone levels and the hepatic antioxidant system in stressed rats, indicating an adaptogenic and hepatoprotective potential of RJ.
束缚和冷应激会增加皮质酮和血糖水平，进而导致肝组织的氧化损伤。本研究评估了补充蜂王浆（RJ）对束缚和冷应激大鼠的皮质酮水平、血糖、血浆酶和肝脏抗氧化系统的影响。将Wistar大鼠分为无应激组、应激组、补充RJ的无应激组和补充RJ的应激组。最初，给予RJ（200mg/Kg），持续14天，应激组从第7天开始接受慢性应激。结果表明，补充RJ可降低应激诱导后的皮质酮水平，并改善血糖控制。补充RJ还降低了体重、天冬氨酸转氨酶（AST）、碱性磷酸酶（ALP）和γ-谷氨酰转移酶（GGT）。此外，RJ提高了肝脏的总抗氧化能力、超氧化物歧化酶（SOD）活性，并降低了谷胱甘肽（GSH）、谷胱甘肽还原酶（GR）和脂质过氧化水平。因此，补充RJ可恢复应激大鼠的皮质酮水平和肝脏抗氧化系统，表明RJ具有适应原性和肝脏保护潜力。
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