Schiuma Giovanna, Beltrami Silvia, Bortolotti Daria, Rizzo Sabrina, Rizzo Roberta
Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, 44121 Ferrara, Italy.
Microorganisms. 2022 Feb 23;10(3):501. doi: 10.3390/microorganisms10030501.
An efficient host immune response is crucial in controlling viral infections. Despite most studies focused on the implication of T and B cell response in COVID-19 (Corona Virus Disease-19) patients or in their activation after vaccination against SARS-CoV-2, host innate immune response has raised even more interest as well. In fact, innate immunity, including Natural Killer (NK) cells, monocytes/macrophages and neutrophils, represent the first line of defense against the virus and it is essential to determine the correct activation of an efficient and specific acquired immune response. In this perspective, we will report an overview on the main findings concerning SARS-CoV-2 interaction with innate host immune system, in correlation with pathogenesis and viral immune escape mechanisms.
有效的宿主免疫反应对于控制病毒感染至关重要。尽管大多数研究聚焦于T细胞和B细胞反应在2019冠状病毒病（COVID-19）患者中的作用或其在接种抗严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗后的激活情况，但宿主的固有免疫反应也引起了更多关注。事实上，固有免疫包括自然杀伤（NK）细胞、单核细胞/巨噬细胞和中性粒细胞，是抵御病毒的第一道防线，对于确定有效且特异性的获得性免疫反应的正确激活至关重要。从这个角度来看，我们将概述关于SARS-CoV-2与宿主固有免疫系统相互作用的主要发现，并将其与发病机制和病毒免疫逃逸机制相关联。
