Department of Obstetrics and Gynecology, Universityof Alberta, Edmonton, Alberta, Canada.
J Leukoc Biol. 2010 Oct;88(4):625-33. doi: 10.1189/jlb.1209796. Epub 2010 Jun 2.
No other organ in the body undergoes such an invasion of selective cells (leukocytes) and release of homing molecules, CAMs, proinflammatory cytokines, and mediators or undergoes similar extensive remodeling of tissues over such a short period of time as the pregnant uterus. This is especially interesting, as an infectious process involving microorganisms does not exist in a healthy pregnancy and delivery. Furthermore, after delivery of the baby and placenta, the uterus involutes and returns to its normal monthly cycling, and most of the leukocytes are swept away or leave. In this review, we discuss leukocyte infiltration and recruitment and the potential roles of each subpopulation of leukocytes in relation to pregnancy and the problems of preterm birth, pre-eclampsia, and intrauterine growth restriction.
在体内没有其他器官像怀孕的子宫那样，会经历如此选择性细胞（白细胞）入侵和归巢分子、细胞间黏附分子、促炎细胞因子和介质的释放，或在如此短的时间内经历如此广泛的组织重塑。这尤其有趣，因为在健康的妊娠和分娩过程中并不存在涉及微生物的感染过程。此外，在婴儿和胎盘娩出后，子宫收缩并恢复到正常的每月循环，大多数白细胞被清除或离开。在这篇综述中，我们讨论了白细胞浸润和募集，以及每种白细胞亚群与妊娠和早产、子痫前期和宫内生长受限等问题的潜在关系。
